Abstract: ob＜x＞jective This study aims to explore the ex＜x＞pression , clinicopathological features and clinical significance of Protein Tyrosine Phosphatase Receptor Type J ( PTPRJ) in gastric cancer tissues. Methods The paraffin samples of cancer tissues and paracancerous tissues from 50 patients who underwent gastric cancer surgery from January 2015 to December 2016 were analyzed retrospectively. Immunohistochemistry was used to detect the ex＜x＞pression structure of PTPRJ in 50 gastric cancer tissues and corresponding adjacent tissues. Results The positive ex＜x＞pression rate of PRPTJ in gastric cancer specimens was 44% (22/50) and the negative ex＜x＞pression rate was 56% (28/50). The positive ex＜x＞pression rate of PTPRJ in gastric cancer adjacent tissues was 68% (34/50) and the negative ex＜x＞pression rate was 32% (16/50). The positive ex＜x＞pression rate in paracancerous tissues was higher than that in cancer tissues , therefore, there was the statistical difference between them (p<0.05). The ex＜x＞pression of PTPRJ was related to tumor cell differentiation, tumor invasion, lymph node me＜x＞tastasis and TNM staging (p <0.05), but not related to age, sex and location (p>0.05). For those with positive ex＜x＞pression of PTPRJ in cancer tissue, the overall survival (OS) was 4 6 month, while for those with negative ex＜x＞pression was 38month. The difference was statistically significant (P =0.033). Conclusion PTPRJ has a higher positive ex＜x＞pression rate in paracancerous tissues than that in cancer tissues, the patients with positive ex＜x＞pression in cancer tissues may benefit from survival. PTPRJ may become a biological marker for diagnosis and prognosis of gastric cancer