Abstract: ob＜x＞jective To explore the prognostic value of NLR(Lneutrophil-to-lymphocyte)、LMR (lymphocyte-to-monocyte ratio)、PLR(platelet-to-lymphocyte ratio）、lactic dehydrogenase in the patient of gastric cancer。Methods In this retrospective analysis,110 patients’clinical data with gastric cancer treated in The Fujian province hospital from January 2009 to June 2019.The clinical information including age and gender,stages,lymphatic me＜x＞tastasis,and the first blood test information were collected.The Kaplan-Meier,Log-rank,Cox were performed for the analysis of prognostic factors.Results A total fo 110 patients were enrolled in this Study,of which I -Ⅱ stage group 40 cases, 70 cases of phase III.All patients were followed up for 13-96 months, with a median follow-up time of 80.9 months.Of the 110 patients followed up, 44 died of gastric cancer and 66 survived.The results of survival analysis of gastric cancer patients with different clinicopathological factors showed that the prognosis of gastric cancer patients was correlated with TNM stage, lymph node me＜x＞tastasis, NLR and LDH (all P<0.05), which was not related to the patient’s age, gender, tumor size, differentiation degree, PLR, and LMR.NLR and PLR were correlated with the degree of tumor differentiation (all P<0.05).The groups of LMR and LDH were related to TNM stage of patients (all P<0.05), and LDH was also related to PT stage, namely local infiltration degree (P<0.05), with statistically significant differences.Cox multivariate regression analysis was performed on the variables affecting the prognosis of patients with gastric cancer, and the results showed that TNM staging, NLR level and LDH were independent factors affecting the prognosis of patients with gastric cancer (all P<0.05).Conclusion TNM stage, NLR level and LDH are independent factors affecting the prognosis of patients with gastric cancer.