Abstract: ob＜x＞jective：On Application of magnetic susceptibility-weighted imaging (SWI) technology in detecting senile lacunar cerebral infarction patients with cerebral microbleeds (CMBS) lesions of value; and the CMBS in patients with aspirin antiplatelet aggregation or anticoagulant therapy after cerebral hemorrhage risk of preliminary study.Method：MRI routine axial FSE sequences (T1WI、T2WI、T2FLAIR), GRE-T2*WI and SWI sequence were performed in lacunar cerebral infarction group, accompanied by micro hemorrhage lacunar cerebral infarction group and healthy elderly group, 60 cases in each.In addition, lacunar cerebral infarction group and accompanied by micro hemorrhage lacunar cerebral infarction group were according to the guidelines for formal antiplatelet or anticoagulant therapy, patients were followed up for 12 months, on the complicated with cerebral hemorrhage were observed, analysis to determine cerebral microbleeds, antiplatelet therapy, anticoagulant therapy and cerebral out blood into the correlation.Result：The two groups of research ob＜x＞jects were related to the scan,SWI scan showed that the positive rate of CMBs was the highest, followed by GRE-T2*WI,and other conventional scanning sequence T1WI, T2WI, T2FLAIR found that the positive rate of CMBs was low.In two groups of 120 cases of SWI sequence found CMBs 84 cases 34, GRE-T2*WI sequence found 40 cases of 18, T1WI and T2WI were found in 4 cases 11 and 6 cases respectively,After chi-square test, the differences between the sequences were statistically significant （P<0.05）.In the lacunar infarction group in 26 cases (43.33%) found that the micro bleeding lesions, while the normal control group was 8 cases (13.33%). Lacunar cerebral infarction group can see the light, medium and severe three types of cerebral microbleeds and normal control group showed slight hemorrhage. Lacunar infarction and cerebral microbleeds were significantly related to severity,P<0.05.patients with CMBs after formal antiplatelet therapy and anticoagulation therapy, patients with CMBS lacunar cerebral infarction group appear cerebral hemorrhage in 1 case, but no statistical significance P>0.05.Conclusion：SWI sequence scan is better than GRE-T2*WI sequence, GRE-T2*WI sequence is superior to the conventional FSE sequence. It is highly sensitive and specific to the diagnosis of cerebral micro hemorrhage. It is an accurate and effective method for the analysis and diagnosis of cerebral micro hemorrhage.Patients with CMBS lacunar cerebral infarction, antiplatelet and anticoagulant therapy, cerebral hemorrhagic transformation of the risk is relatively small within 12 months, but the need to further extend the observation period to clear the long-term risks