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    夏文亚, 甘言刚, 陈安珉, 陈蕴, 黄建槐, 汤静, 冯锦红. SII、NLR、肌酐和CRP对新冠肺炎患者并发AKI的预测价值[J]. 徐州医科大学学报, 2021, 41(10): 753-758. DOI: 10.3969/j.issn.2096-3882.2021.10.009
    引用本文: 夏文亚, 甘言刚, 陈安珉, 陈蕴, 黄建槐, 汤静, 冯锦红. SII、NLR、肌酐和CRP对新冠肺炎患者并发AKI的预测价值[J]. 徐州医科大学学报, 2021, 41(10): 753-758. DOI: 10.3969/j.issn.2096-3882.2021.10.009
    shu
    Predictive value of SII, NLR, CRP combined with creatinine in covid-19 complicated with AKI[J]. Journal of Xuzhou Medical University, 2021, 41(10): 753-758. DOI: 10.3969/j.issn.2096-3882.2021.10.009
    Citation: Predictive value of SII, NLR, CRP combined with creatinine in covid-19 complicated with AKI[J]. Journal of Xuzhou Medical University, 2021, 41(10): 753-758. DOI: 10.3969/j.issn.2096-3882.2021.10.009
    shu

    SII、NLR、肌酐和CRP对新冠肺炎患者并发AKI的预测价值

    Predictive value of SII, NLR, CRP combined with creatinine in covid-19 complicated with AKI

      摘要
    • 摘要: 目的 ：探讨新型冠状病毒肺炎（COVID-19）对肾脏的影响及发生急性肾损伤的危险因素。方法：回顾性分析2020年1月20日至2020年3月1日在江苏省8家定点医院新冠肺炎确诊患者的临床资料。根据血肌酐值，将入组患者分为急性肾损伤（AKI）组和非急性肾损伤组。结果：单因素分析显示：在年龄、合并高血压、合并糖尿病、严重程度、发生呼吸衰竭、入住ICU、发生呼吸困难、白细胞计数、中性粒细胞计数、全身免疫炎症指数（SII）、中性粒细胞与淋巴细胞计数比值（NLR）、乳酸脱氢酶、总胆红素、白蛋白、血糖、尿素、肌酐、尿酸、钙离子、氯离子、D-二聚体、C反应蛋白（CRP）等方面，组间差异有统计学意义（P<0.05)。其余一般资料及实验室指标无统计学意义（P>0.05）。二元Logistic回归分析显示：SII、NLR、肌酐、C反应蛋白升高是COVID-19患者发生急性肾损伤的独立危险因素。描绘ROC曲线后计算AUC，评价其的预后价值。结论：SII、NLR、肌酐、C反应蛋白为COVID-19患者发生急性肾损伤的独立危险因素，具有预测COVID-19患者肾脏功能损伤程度及临床预后的价值。

       

      Abstract: ob＜x＞jectIVE: To investigate the effects of COVID-19 on kidney and the risk factors of acute kidney injury.METHODS: The clinical data of patients diagnosed with COVID-19 in 8 designated hospitals in Jiangsu Province on January 20, 2020 were retrospectively analyzed. According to the serum creatinine value, the patients were divided into acute kidney injury (AKI) group and non-acute kidney injury group.RESULTS: Univariate analysis showed that there was statistically significant difference between groups in age, hypertension, diabetes mellitus, severity, respiratory failure, ICU admission, dyspnea, leukocyte count, neutrophil count, systemic immune inflammatory index（SII）， neutrophils and lymphocytes count ratio (NLR), lactate dehydrogenase, total bilirubin, albumin, glucose, urea, creatinine, uric acid, filtration rate, calcium ion, chloride ion, D- Dimer, c-reactive protein (CRP). Other general data and laboratory indicators had no statistical significance (P>0.05). Binary Logistic regression analysis showed that SII, NLR, creatinine and CRP were independent risk factors for acute kidney injury in COVID-19 patients.CONCLUSIONS: SII, NLR, creatinine and CRP are independent risk factors for acute kidney injury in patients with COVID-19, and have value in predicting the degree of renal function injury and clinical prognosis in patients with COVID-19

       

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