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    高擎, 周俊山. 血清HDL及UA与机械取栓术后脑梗死患者早期神经功能改善和sICH的相关性[J]. 徐州医科大学学报, 2021, 41(11): 817-822. DOI: 10.3969/j.issn.2096-3882.2021.11.007
    引用本文: 高擎, 周俊山. 血清HDL及UA与机械取栓术后脑梗死患者早期神经功能改善和sICH的相关性[J]. 徐州医科大学学报, 2021, 41(11): 817-822. DOI: 10.3969/j.issn.2096-3882.2021.11.007
    shu
    Correlations of serum HDL and UA with early neurological improvement and symptomatic intracranial hemorrhage after intravascular mechanical thrombectomy in patients with acute cerebral infarction[J]. Journal of Xuzhou Medical University, 2021, 41(11): 817-822. DOI: 10.3969/j.issn.2096-3882.2021.11.007
    Citation: Correlations of serum HDL and UA with early neurological improvement and symptomatic intracranial hemorrhage after intravascular mechanical thrombectomy in patients with acute cerebral infarction[J]. Journal of Xuzhou Medical University, 2021, 41(11): 817-822. DOI: 10.3969/j.issn.2096-3882.2021.11.007
    shu

    血清HDL及UA与机械取栓术后脑梗死患者早期神经功能改善和sICH的相关性

    Correlations of serum HDL and UA with early neurological improvement and symptomatic intracranial hemorrhage after intravascular mechanical thrombectomy in patients with acute cerebral infarction

      摘要
    • 摘要: 目的探讨血清高密度脂蛋白（HDL）及尿酸（UA）水平与机械取栓术后脑梗死患者的早期神经功能改善和症状性颅内出血（sICH）的关系。方法回顾性纳入553例因脑梗死入院并行机械取栓的患者，记录入院时美国国立卫生研究院卒中量表（NIHSS）评分及是否发生sICH等相关基线资料。利用入院时与术后24 h NIHSS评分的差值将患者分为早期神经功能改善良好组及改善不良组。利用多变量Logistic回归模型确定早期神经功能改善和发生sICH的独立影响因素。结果早期神经功能改善良好组血清HDL及UA水平均明显高于改善不良组（P<0.05）；非sICH组血清UA水平显著高于sICH组（P<0.05），而血清HDL水平不是sICH发生的影响因素（P＞0.05）。结论血清高HDL和高UA是机械取栓术后脑梗死患者早期神经功能改善的独立保护因素，且血清高UA可能降低sICH的发生率。

       

      Abstract: ob＜x＞jective To explore the correlations of serum high density lipoprotein (HDL) and uric acid (UA) with early neurological improvement (ENI) and symptomatic intracranial hemorrhage(sICH) after thrombectomy in patients with acute cerebral infarction. Methods 553 patients with cerebral infarction who received intravascular mechanical thrombectomy were retrospectively analyzed. National Institutes of Health Stroke Scale (NIHSS) scores, occurrence of sICH and other ba＜x＞seline informations were recorded. The different value of NIHSS between admission time and 24h after thrombectomy was used to evaluate the ENI. Multivariate logistic regression models were used to observed the independent factors for ENI and sICH. Results Serum HDL and UA w ere obviously higher in good ENI group than in poor ENI group ( P<0.05). Besides, s erum UA was distinc tly higher in the non-sICH group than in the sICH group (P<0.05). However, there was no significant c orrelation between HD L and the onset of sICH(P＞0.05). Conclusion High serum HDL and UA level s are independently associated with good ENI after thrombectomy in patients with cerebral infarction, and high serum UA may be a protective factor for lowering the occurrence of sICH

       

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