Abstract: ob＜x＞jectice To compare whether anterior cervical discectomy and fusion (ACDF) was superior to anterior cervical corpectomy and fusion (ACCF) in the treatment of two-adjacent-level degenerative cervical spondylosis. Methods 40 patients with cervical degenerative disease who underwent ACDF or ACCF were included in this retrospective analysis. The patients were divided into ACDF group and ACCF group according to the type of operation they received. In ACDF group, polyether ether ketone (PEEK) was used as the intervertebral cage, and in ACCF group, titanium mesh (TMC) was used as the intervertebral cage. Perioperative parameters (hospital stay, blood loss, operation time, and complications), clinical outcomes (Japanese Orthopaedic Association scores and visual analogue scale scores for neck and arm pain), and fusion status were evaluated. Results Compared with ACDF group, the average operation time of ACCF group was significantly shorter (P < 0.05), the blood loss during operation was increased (P < 0.05), and there was no difference in hospitalization time between the two groups (P > 0.05). During the follow-up period, JOA score and VAS score of neck and upper limb were significantly improved in both groups, but there was no difference between two groups. In ACCF group, 3 patients had TMC subsidence and 1 needed revisional surgery. There were no obvious complications in ACDF group. Conclusion The two procedures yielded comparable results in terms of clinical and radiological outcomes. However, when compression at the vertebral level is mild to moderate, we suggest the use of ACDF than ACCF because of the possibility of early hardware failure.