Abstract: ob＜x＞jective To investigate the clinicopathologic characteristics and prognosis of renal cell carcinoma (RCC) in patients older than 70 years. Methods Between January 2008 and December 2018, the clinicopathologic and follow-up data of patients older than 70 years with RCC at our institution were retrospectively evaluated. The endpoint was overall survival (OS). The Kaplan-Meier method was used to graphically display survivor functions. The Cox proportional hazards model was used for univariable and multivariable survival analyses. Results: A total of 187 patients were enrolled in this study, including 135 males (72.2%), with 121 laparoscopic surgery (64.7%) and 159 radical nephrectomy (85.0%).The prevalence of hypertension, diabetes mellitus, anemia and hypoproteinemia were 46.5%, 18.7%, 33.7% and 35.8%, respectively. Clear cell renal cell carcinoma is the most common pathological subtype of RCC (163, 87.2%). The 1-, 3-, 5-year OS rates were 96.2%, 85.7% and 71.1%, respectively. Cox multivariable analysis showed that AJCC stages (95% CI:1.450-2.758, P＜0.001) and pathological types (95% CI:0.189-0.764, P=0.007) were factors influencing the OS. In T1a stage subgroup, radical nephrectomy and partial nephrectomy showed similar prognosis and hemoglobin