Abstract: ob＜x＞jective To observe the recurrence and immune modulatory effect of pidotimod combined valaciclovir tablets in treating recurrent genital herpes(GH)．Methods 72 patients were divided into two groups randomly．The treatment group included 36 cases and the control group included 36 cases．The treatment group was treated with pidotimod combined with valaciclovir tablets，while the control group was treated with valaciclovir tablets only．The drug use of these two groups lasted four months．The immunologic function of patients was detected before and after treatment and the recurrence rate of two groups was compared．Results The clinical effective rate of the treatment group was significantly higher than that of the control group,and the difference between the 2 groups was significant(P<0.05). The 2 groups were followed up for 12 months,and the recurrence rate of the treatment group was significantly lower than that of the control group .The CD3+ (53.12±4.02）%、CD4+ （41.21±2.68）% and CD4+/CD8+ （1.21±0.18）% ratio of the treatment group raised and CD8+（33.21±2.58）% lowered after treatment, The CD3+（50.98±3.92）%、CD4+（33.11±3.01）%、CD4+／CD8+（0.91±0.38）%、CD8+（40.11±2.08）% ratio of the control group after treatment,the differences were statistically significant（P<0.05）.while before treatment the above mentioned parameters were not changed significantly． Conclusion pidotimod combined valaciclovir tablets has immune modulatory effect on patients with recurrent genital herpes，and it could reduce the recurrence rate and exact effect，is worthy of clinical application．