Abstract: Bed nucleus of stria terminalis (BNST) integrat es the information from limbic system and transfer s to the hypothalamus and brainstem . It plays an important role in stress, fear memor y, social behavior and so on . Its complexity of the structure determines the diversity of the function. T he physiological functions of various BNST subnuclear have become a research hotspot, but the underlying mechanisms remain largely unclear. This review summarized the physiological function of different region in BNST according to the general anatomical division that has gained recognition, providing a more comprehensive and effective reference for future studies of BNST.