高级检索
    刘海红. 哮喘、慢阻肺及哮喘-慢阻肺患者血清中IgE、CRP、IL-6的比较及临床意义[J]. 徐州医科大学学报, 2022, 42(1): 7-12. DOI: 10.3969/j.issn.2096-3882.2022.01.002
    引用本文: 刘海红. 哮喘、慢阻肺及哮喘-慢阻肺患者血清中IgE、CRP、IL-6的比较及临床意义[J]. 徐州医科大学学报, 2022, 42(1): 7-12. DOI: 10.3969/j.issn.2096-3882.2022.01.002
    shu
    Comparison and clinical significance of serum IgE, CRP, IL-6 in patients with asthma, chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease[J]. Journal of Xuzhou Medical University, 2022, 42(1): 7-12. DOI: 10.3969/j.issn.2096-3882.2022.01.002
    Citation: Comparison and clinical significance of serum IgE, CRP, IL-6 in patients with asthma, chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease[J]. Journal of Xuzhou Medical University, 2022, 42(1): 7-12. DOI: 10.3969/j.issn.2096-3882.2022.01.002
    shu

    哮喘、慢阻肺及哮喘-慢阻肺患者血清中IgE、CRP、IL-6的比较及临床意义

    Comparison and clinical significance of serum IgE, CRP, IL-6 in patients with asthma, chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease

      摘要
    • 摘要: 目的探讨哮喘、慢性阻塞性肺疾病（简称慢阻肺）及哮喘-慢阻肺患者血清中免疫球蛋白E（IgE）、C反应蛋白（CRP）、白介素-6（IL-6）的变化及临床意义。方法选取2018年3月—2020年1月北京中医药大学房山医院65例哮喘-慢阻肺患者作为研究组，另选65例单纯哮喘、65例单纯慢阻肺患者分别作为对照组A、对照组B。检测比较3组一般资料、血清IgE、CRP、IL-6水平、肺功能指标〔第1秒用力呼气容积占预计值百分比（FEV1%）、用力肺活量（FVC）〕、血气分析指标〔动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）〕，评价血清IgE、CRP、IL-6与肺功能指标、血气分析指标的关系，探究血清IgE、CRP、IL-6诊断哮喘-慢阻肺的价值，统计研究组治疗3个月后预后情况，比较不同预后患者治疗前一般资料、治疗1周、3周后血清IgE、CRP、IL-6水平。结果研究组血清IgE、CRP、IL-6水平及PaCO2均高于对照组A、对照组B，FEV1%、FVC、PaO2均低于对照组A、对照组B（P＜0.05）；血清IgE、CRP、IL-6与FEV1%（r=-0.674、-0.489、-0.716）、FVC（r=-0.689、-0.715、-0.691）及PaO2（r=-0.884、-0.789、-0.821）呈负相关，与PaCO2（r=0.664、0.514、0.646）呈正相关（P＜0.05）；血清IgE、CRP、IL-6联合诊断哮喘-慢阻肺的曲线下面积（AUC）为0.876，大于各指标单独诊断（0.817、0.846、0.737），联合诊断的最佳敏感度、特异度分别为75.38%、89.23%；研究组预后良好患者治疗3周后血清IgE、CRP、IL-6水平均低于预后不良患者（P＜0.05）。结论哮喘-慢阻肺患者血清中IgE、CRP、IL-6明显升高，早期明确各指标水平可在一定程度上反映患者肺功能及血氧状态，且与患者预后有关，可为哮喘-慢阻肺的临床诊断、治疗提供重要信息。

       

      Abstract: To explore the comparison and clinical significance of serum immunoglobulin E (IgE), C-reactive protein (CRP) and interleukin-6 (IL-6) in patients with asthma, chronic obstructive pulmonary disease and asthma-chronic obstructive pulmonary disease. Methods: From March 2018 to January 2020, 65 patients with asthma-chronic obstructive pulmonary disease in our hospital were selected as the study group, and 65 patients with simple asthma and 65 patients with simple chronic obstructive pulmonary disease were selected as control group A and control group B, respectively. The general data, serum IgE, CRP, IL-6 levels, lung function indicators forced expiratory volume in the first second as a percentage of predicted value (FEV1%), forced vital capacity (FVC), and blood gas analysis indexes arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2) of the 3 groups were detected and compared. The relationship between serum IgE, CRP, IL-6 and pulmonary function indexes and blood gas analysis indexes was evaluated, and the value of serum IgE, CRP, IL-6 in the diagnosis of asthma-chronic obstructive pulmonary disease was explored. The prognosis of the study group after 3 months of treatment was calculated. The general data of patients with different prognosis before treatment, serum IgE, CRP, and IL-6 levels after 1 week and 3 weeks of treatment were compared, and the correlation between serum IgE, CRP, IL-6 and the prognosis of asthma-chronic obstructive pulmonary disease was explored.

       

      • HTML全文
      • 参考文献(0)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回