Abstract: ob＜x＞jective: To study the clinical effect of ziprasidone injection in the treatment of psychiatric emergency schizophrenic agitation patients. Methods: In this study, a prospective study was conducted. 118 cases of psychiatric emergency schizophrenic agitation patients treated in our hospital from January 2017 to January 2019 were selected as the research ob＜x＞jects. According to the principle of random grouping, the above patients were randomly divided into two groups, the observation group and the control group, 59 cases in each group. The observation group was treated with ziprasidone and the control group was treated with haloperidol for 3 days. The differences of PANSS score, panss-ec score and bars score between the two groups were observed. Results: The total effective rate of the observation group (89.83%) was significantly higher than that of the control group (74.58%) (χ 2 = 4.692, P = 0.030). After 30 minutes and 2 hours of treatment, the panss-ec and bars scores of the two groups were significantly decreased, and the panss-ec (t = 3.401, 9.812, P < 0.05) and bars scores (t = 2.120, 2.519, P < 0.05) of the observation group were significantly lower than those of the control group; there was no significant difference between the two groups in terms of sedentary disability (χ 2 = 0.165, P = 0.684), weight gain (χ 2 = 0.521, P = 0.470), dry mouth constipation (χ 2 = 0.179, P = 0.672) and tachycardia (χ 2 = 0.202, P = 0.657). Conclusion: Ziprasidone injection in the treatment of psychiatric emergency schizophrenic agitation patients, PANSS score, panss-ec and bar score were significantly reduced, the treatment effect was significant, it is recommended to promote