Abstract: Objective To explore the risk factors of infantile hemangioma. Methods A case-control study was conducted based on the dermatology department of Xuzhou children’s hospital. The cases were composed of 248 infants with superficial infantile hemangioma, and 248 infants without infantile hemangioma with the same gender and similar of age were selected as the control group. Logistic regression model was used to analyze the risk factors of infantile hemangioma, and the odds ratio of risk factors and 95% confidence interval were calculated. Results Five statistically significant variables were screened by univariate logistic regression, and multivariate logistic regression was performed. Birth weeks (<37 weeks: P=0.124, OR=3.523, 95%CI=0.708-17.532; 37-41 weeks: P=0.559, OR=1.467, 95%CI=0.405-5.315), family history (P<0.001, OR=11.816, 95%CI=3.487-40.042), placenta previa (P=0.001, OR=6.034, 95%CI=2.005-18.156), number of births (P=0.006, OR=0.592, 95%CI=0.406-0.863), maternal hypertension (P=0.025, OR=2.749). Conclusion Family history, maternal hypertension, placenta previa and birth order are risk factors for infantile hemangioma.