Abstract: ob＜x＞jective:To establish and verify the risk prediction model of postoperative bleeding in elderly gastric cancer patients with long-term anticoagulation, and to provide reference for nursing work. Methods:The clinical data of 30 gastric cancer patients with bleeding after gastrectomy and 200 elderly gastric cancer patients without bleeding after gastrectomy were analyzed, retrospectively.Statistical methods were used to analyze the risk factors of postoperative bleeding and the prediction model was established. The receiver operating characteristic (ROC) curve was used to evaluate the predictive performance of the risk prediction model. The difference of postoperative clinical manifestations between the case group and the control group were compared. Results: Multivariate analysis showed that platelets<100×109/L, TNM stage III and abdominal infection were independent risk factors for postoperative bleeding in elderly patients with gastric cancer. The AUC of the established bleeding risk prediction model was 0.753 (95% CI:0.692~ 0.807), with sensitivity of 60.00% and specificity of 79.00%. The incidence of hematemesis, black stool and abnormal drainage fluid in the case group was significantly higher than that in the control group (P < 0.05).Conclusion: Low platelet level, advanced patients and postoperative abdominal infection were independent risk factors of postoperative bleeding in elderly patients with long-term anticoagulant gastric cancer. For this kind of patient,clinical nurses need to be alert for the occurrence of postoperative bleeding according to the clinical feature .