Abstract: Objective: To review the results of serum thyrotropin examination in the population of more than 1915 institutions and institutions at an altitude of 2600 meters at an altitude, and to explore the factors affecting the abnormal expression of serum thyrotropin. Methods:In September 2017, thyroid function tests were performed on 1915 organs and institutions in a city of 2,600 meters above sea level. The fasting serum was tested for thyroid function, thyroid hormone, triiodothyronine, free thyroxine, and free triiodothyroglastin. The indicators of amino acids, analysis of test results, and discussion of the factors affecting the abnormal expression of thyroid stimulating hormone. Results:The test results showed that there were 321 cases of serum thyroid-stimulating abnormalities among 1915 residents in high-altitude cities, accounting for 16.76% (321/1915). 321 cases of serum serum thyroid stimulating compared with normal significant difference, thyroxine, triiodothyronine, free thyroxine, free triiodothyronine and normal no difference. Analysis by SPSS 21.0 software showed that age, sex, and elevation had a greater impact on serum thyroid-stimulating.Conclusion:The probability of abnormal rise of serum thyrotropin in the 2600 meters high plateau urban population is higher, suggesting that the incidence of hypothyroidism in the population is higher, and the thyroid function monitoring should be strengthened for women in pregnancy. It is worth popularizing and widely used in clinic.