Abstract: ob＜x＞jective: To compare the clinical effects of laparoscope-assisted and modified transanal Soave in the treatment of popular type hirschsprung’s disease in neonates (HD). Methods: The clinical data of 65 popular type HD neonates admitted to our hospital were retrospectively analyzed. The patients were divided into observation group (35 cases) and control group (30 cases) according to different surgical methods. The control group was treated with modified anal Soave surgery alone, and the observation group was treated with modified anal Soave surgery under the assistance of laparoscopy. The perioperative conditions, surgical effects and complications of the two groups were compared. Results: The operation time and length of intestinal resection in the observation group were significantly longer than control group, the anal anatomy time and postoperative hospitalization time were significantly shorter, and the intraoperative blood loss was significantly less (P<0.05). There was no significant difference in postoperative anal exhaust time between the two groups (P>0.05). The excellent and good rates of anal function in the observation group respectively were 84.38% and 100.00% at 6 and 12 months after surgery, which were significantly higher than those in the control group (77.78% and 88.00%, both P<0.05). Compared with the preoperative, two groups of children of 6 months and 12 months after the anus were significantly lower, rectal resting pressure Angle were significantly increased, and the change range of observation group is smaller, the observation group after 6 months, 12 months of anal resting pressure levels were significantly higher than that of control group, rectal Angle were significantly lower than control group (P<0.05). The total incidence of postoperative complications was 20.00% in the observation group and 46.67% in the control group, and the difference was statistically significant (P<0.05).Conclusion: Compare with the single modified anal Soave operation, laparoscopic-assisted modified anal Soave operation for the treatment of popular type HD has shorter anal operation time, less intraoperative blood loss, less damage to anal sphincter, less anastomotic tension and fewer postoperative complications, with more significant therapeutic effect and higher safety.