Abstract: ob＜x＞jective to evaluate the efficacy of a new collagen and hyaluronic acid dressing for healing of wounds induced by erbium fractionated laser treatment of atrophic scar in facial acne. Methods 46 patients from the outpatient department were recruited and randomly divided into treatment and control groups (23 cases in each group) . Both groups were then treated by two sessions of Erbium fractionated laser with an interval of one month. After each session of laser therapy, the treatment group were topically treated with a collagen and hyaluronic acid dressing for 20 minutes once a day during a 7 -day session, while a Saline-soaked gauze was applied to the control group. The 46 patients were followed up for 3 months after treatment to moniter the acute inflammatory response, scab sheddig time and patient comfort level. The incidence of post-inflammatory hyprepigmentation, the red areas assessment with VISIA skin tester, and other adverse reaction were also assessed. Results There were significant differences between treatment and control groups in acute inflammatory response score (2=9.544, P<0.05), patient comfort level after laser surgery (2=7.413, P<0.05) and incidence of hyprepigmentation (2=4.212, P<0.05) by Chi-square test. The scab shedding time(t =5.338, P<0.001) of treatment group has shorten and the red area score under VISIA (t=4.553,P<0.001)was significantly lower than that of the control group.Conclusion The application of a new collagen and hyaluronic acid dressing with tranexamic acid, dipotassium glycyrrhizinate after Erbium fractionated laser treatment can reduce both the incidence of adverse reactions and the time of scab shedding, but accelerate the recovery of skin erythema after Erbium fractionated laser therapy