急性脑梗死患者血清Trx、TrxR水平与早期神经功能恶化的关系

刘研; 高思睿

doi:10.3969/j.issn.2096-3882.2022.10.010

急性脑梗死患者血清Trx、TrxR水平与早期神经功能恶化的关系

刘研,
高思睿

The relationship between serum Trx, TrxR levels and early neurological deterioration in patients with acute cerebral infarction

摘要

摘要: 目的探讨急性脑梗死患者血清硫氧还蛋白（Trx）、硫氧还蛋白还原酶（TrxR）水平与早期神经功能恶化（END）的关系。方法选择2020 年1月1至2021年12月31日经我院收治的156例急性脑梗死患者作为研究组，并根据是否发生END分为END组（n=68），非END组（n=88），同时将同期在本院进行体检的70例健康志愿者作为对照组。所有纳入对象入院后采用酶联免疫吸附法检测血清Trx、TrxR水平变化；分析比较各组临床基线资料以及血清Trx、TrxR水平；同时采用绘制受试者工作特征曲线（ROC）和曲线下面积（AUC）分析Trx、TrxR对急性脑梗死发生END的预测价值；采用多因素logistic回归分析影响急性脑梗死发生END的相关因素。结果研究组血清Trx水平明显高于对照组（ P<0.05），血清TrxR水平明显低于对照组（P<0.05）；END组患者血清Trx、TrxR水平均高于非END组（P<0.05）；ROC曲线结果显示：Trx、TrxR预测急性脑梗死发生END的曲线下面积分别为0.802、0.830，截断值分别为12.30ng/ml、1.95U/mL，敏感度分别为80.63%、79.21%，特异度分别为85.66%、89.85%，二者联合预测急性脑梗死发生END的曲线下面积为0.910，敏感度为90.88%，特异度为82.31%。多因素logistic回归析结果显示，血清Trx、TrxR水平及NHISS评分均能够作为影响急性脑梗死发生END的危险因素（P<0.05）。结论急性脑梗死患者血清中Trx水平升高、TrxR水平降低，血清Trx、TrxR水平在发生END患者中均降低，二者是急性脑梗死发生END的影响因素，可作为临床评估急性脑梗死发生END的有效指标。

Abstract: ob＜x＞jective: To investigate the relationship between serum thioredoxin (Trx) and thioredoxin reductase (TrxR) levels and early neurological deterioration (END) in patients with acute cerebral infarction. Methods: A total of 156 patients with acute cerebral infarction admitted to our hospital from January 1, 2020 to December 31, 2021 were selected as the research group, and were divided into END group (n=68) and non-END group (n=88) according to whether END occurred or not, and 70 healthy volunteers who underwent physical examination in our hospital during the same period were used as the control group. Serum Trx and TrxR levels were detected by enzyme-li＜x＞nked immunosorbent assay after admission in all included subjects. The clinical ba＜x＞seline data and serum Trx and TrxR levels of each group were analyzed and compared. The receiver operating characteristic curve (ROC) and area under the curve (AUC) was used to analyze the predictive value of Trx and TrxR on END in acute cerebral infarction. The related factors affecting END in acute cerebral infarction were analyzed by multivariate logistic regression analysis. Results: The serum Trx level in the study group was higher compared with control group ( P<0.05), and the serum TrxR level was lower compared wit control group ( P<0.05). The serum Trx and TrxR levels in the END group were higher than those in the non-END group (P<0.05). The results of the ROC curve showed that the areas under the curve of Trx and TrxR for predicting END of acute cerebral infarction were 0.802 and 0.830, respectively, the cut-off values were 12.30 ng/ml and 1.95 U/mL, and the sensitivity was 80.63% and 79.21%, and the specificity were 85.66% and 89.85%, respectively. The area under the curve of the two combined to predict the occurrence of END in acute cerebral infarction was 0.910, the sensitivity was 90.88%, and the specificity was 82.31%. Multivariate logistic regression analysis showed that serum Trx, TrxR levels and NHISS scores were risk factors for END in acute cerebral infarction( P<0.05). Conclusion: Serum levels of Trx increased and TrxR levels decreased in patients with acute cerebral infarction. Serum levels of Trx and TrxR are both decreased in patients with END. Both are influencing factors of END in patients with acute cerebral infarction, and can be used as clinical evaluation indicators for END in patients with acute cerebral infarction

HTML全文

参考文献(0)

施引文献

资源附件(0)