Abstract: ob＜x＞ject To analyze the relationship between the ex＜x＞pression of progesterone receptor (PR), dermatopontin (DPT) and transfermation growth factor β1(TGF-β1) and clinicopathology in endometrial carcinoma (EC). Methods A total of 80 patients with EC, and 30 patients with atypical hyperplasia endometrial disease and 30 patients with normal hyperplasia endometrial tissue diagnosed by pathological examination in Pizhou Hospital Affiliated to Xuzhou Medical University and Xuzhou Central Hospital from September 2013 to April 2016. The ex＜x＞pression and location of PR, DPT and TGF-β1 was detected by immunohistochemistry (SP method ) in EC tissue, atypical hyperplasia endometrial tissue and normal hyperplasia endometrial tissue. The relationship between PR, DPT and TGF-β1 and clinicopathological characteristic of endometrial cancer patients were analyzed. Furthermore, the correlation between PR, DPT and TGF-β1 was also analyzed. Results The positive ex＜x＞pression rate of PR and DPT was significantly decreased in normal endometrial tissue, atypical hyperplasia endometrial tissue and endometrial carcinoma tissue in order (P<0.05), while the positive ex＜x＞pression rate of TGF-β1 was significantly increased in turn (P<0.05), the location of these protein was localized in the nucleus or /and cytoplasm. The ex＜x＞pression level of PR in endometrial cancer tissue was significantly different in histological grade, myometrial invasion depth and lymph node me＜x＞tastasis (P<0.05), the ex＜x＞pression level of DPT was significantly different in histological grade and lymph node me＜x＞tastasis (P<0.05), the ex＜x＞pression level of TGF-β1 was significantly different in histological grade, pathological stage and myometrial depth (P<0.05). Further correlation analysis found that the ex＜x＞pression of PR was positively correlated with DPT (r=0.28, P=0.012), while the ex＜x＞pression of PR was negatively correlated with TGF-β1(r=-0,224, P=0.047). Conclusion The positive ex＜x＞pression rate of PR and DPT was significantly decreased in endometrial carcinoma, while the positive ex＜x＞pression rate of TGF-β1 was significantly increased. The ex＜x＞pression of PR was positively correlated with DPT, but negatively correlated with TGF-β1. These proteins can effectively reflect the malignant progression of endometrial lesions, and is benefit for the clinical detection, diagnosis and treatment of endometrial carcinoma.