Abstract: ob＜x＞jective:To analyze the effect of acid-ba＜x＞se imbalance on myocardial enzymes in full-term neonates with hyperbilirubinemia. Methods:1. According to the group criteria, 100 cases of full-term neonatal hyperbilirubinemia in the neonatal department of Nanjing Medical University’s Second Affiliated Hospital from October 2018 to June 2021 were randomly selected as non-etiological jaundice groups. Another 100 cases of ABO hemolytic jaundice, 100 cases of asphyxia and 100 cases of pneumonia were secondary jaundice or other disease control groups. Grouped by Bhutani hour bilirubin column chart was high-risk jaundice group (61 cases), middle-risk group (39 cases), hemolytic high-risk jaundice group (50 cases), and middle-risk group (50 cases). Correlation analysis serum total bilirubin, myocardial enzymes spectrum, blood electrolyte, blood routine, blood gas analysis. Correlation analysis of the balance of myocardial enzymes and acid-ba＜x＞se. Results:1. There were significant differences between the cardiomyoenzyme spectrum (P<0.05), no significant differences between the non-etiological jaundice group and the pneumonia group Creatine kinase MB (CK-MB) (P>0.05), and no significant difference between Cardiac troponin T (cTnT) in the asphyxia group (P>0.05). 2. There was no difference in myocardial enzymes between different degrees of non-etiological jaundice groups, and between hemolytic jaundice groups to varying degrees (P>0.05). 3. There was no significant difference between the acid-ba＜x＞se imbalance groups (P>0.05), but there were significant differences between myoglobin Myohemoglobin (Myo) and cTnT (P<0.05) and related to the imbalance type. Conclusion:Full-term neonatal hyperbilirubinemia has the same degree of heart muscle enzyme changes as neonatal asphyxia, myocardial enzyme changes are not related to jaundice degree, and are related to acid-ba＜x＞se imbalance. Attention should be paid to the judgment of triple acid-ba＜x＞se imbalance of blood gas, which is beneficial to the analysis of hyperbilirubinemia and other heart muscle damage in children in newborns and provides the basis for clinical diagnosis and treatment.