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    汪浩森, 胡丹, 辛鑫, 王祥雷, 姜朕. 小儿危重病例评分联合尿酸、同型半胱氨酸对儿童脓毒症相关性脑病的诊断意义[J]. 徐州医科大学学报, 2022, 42(11): 844-848. DOI: 10.3969/j.issn.2096-3882.2022.11.012
    引用本文: 汪浩森, 胡丹, 辛鑫, 王祥雷, 姜朕. 小儿危重病例评分联合尿酸、同型半胱氨酸对儿童脓毒症相关性脑病的诊断意义[J]. 徐州医科大学学报, 2022, 42(11): 844-848. DOI: 10.3969/j.issn.2096-3882.2022.11.012
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    Diagnostic significance of PCIS combined with UA and Hcy in children with sepsis associated encephalopathy[J]. Journal of Xuzhou Medical University, 2022, 42(11): 844-848. DOI: 10.3969/j.issn.2096-3882.2022.11.012
    Citation: Diagnostic significance of PCIS combined with UA and Hcy in children with sepsis associated encephalopathy[J]. Journal of Xuzhou Medical University, 2022, 42(11): 844-848. DOI: 10.3969/j.issn.2096-3882.2022.11.012
    shu

    小儿危重病例评分联合尿酸、同型半胱氨酸对儿童脓毒症相关性脑病的诊断意义

    Diagnostic significance of PCIS combined with UA and Hcy in children with sepsis associated encephalopathy

      摘要
    • 摘要: 目的 探讨小儿危重病例评分（PCIS）、尿酸（UA）和同型半胱氨酸（Hcy）诊断儿童脓毒症相关性脑病（sepsis associated encephalopathy，SAE）的意义。 方法 回顾性纳入2019年2月～2022年2月徐州市儿童医院重症医学科（PICU）收治脓毒症患儿267例，分为SAE组（n=90例）和非SAE组（n=177例）。比较两组研究对象一般资料及相关指标，分析SAE发生的危险因素。受试者工作特征曲线（receiver operating characteristic curve，ROC）评估PCIS、UA和Hcy诊断儿童SAE的敏感度、特异性及最佳临界值。 结果 PCIS联合UA、Hcy诊断SAE的AUC值为0.981，敏感度为96.67%，特异性为89.27%，差异有统计学意义（P<0.05）。结论 PCIS、UA和Hcy对儿童SAE有一定的诊断价值。

       

      Abstract: 0bjective This study investigated the significance of pediatric critical illness score (PCIS), uric acid (UA) and homocysteine (Hcy) in the diagnosis of sepsis associated encephalopathy (SAE) in children. Methods A total of 267 children with sepsis treated in the pediatric intensive care unit of Xuzhou Children’s Hospital from February 2019 to February 2022 were retrospectively included. They were divided into SAE group (n = 90 cases) and non-SAE group (n = 177 cases). The general data and related indicators of the two groups were compared, and the risk factors of SAE were analyzed. Receiver operating characteristic curve (ROC) was used to evaluate the significance and optimal threshold of PCIS, UA and Hcy in the diagnosis of SAE in children. Results The AUC value of SAE diagnosed by PCIS combined with UA and Hcy was 0.981, the sensitivity was 96.67%, and the specificity was 89.27%. The difference was statistically significant (P < 0.05). Conclusions PCIS,UA and Hcy were valuable in the diagnosis of SAE in children.

       

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