Abstract: Background: Gastrointestinal neuroendocrine neoplasias(GI-NENs) G1/ G2 are well differentiated, but me＜x＞tastasis or local recurrence still occurs?in a small proportion of patients, thus affecting their survival.Limited by rare diseases, there are few studies on the clinicopathological characteristics and prognosis of GI-NENsG1/ G2 .ob＜x＞jective:To explore the clinicopathological features of GI-NENs G1/G2 on overall survival (OS) and disease-free survival (DFS).Methods:Clinicopathological materials and follow-up data of 94 patients of GI-NENs G1/G2 were analyzed retrospectively at Yixing Hospital affiliated to Jiangsu University between January 2011 to December 2020,Survival analysis was evaluated by?Kaplan-Meier and prognostic factors was analyzed by Cox?proportional hazards model.Results:Among the the 94 patients, 45 (47.9%) were male, the?mean?age?was?55.32±13.19?years.the mean lesion diameter was 0.84±0.80cm, the main treatment modality were surgical?resection and?endoscopic?resection, The?R0?resection rate was 89.4%.Furthermore, 40 (42.6%) cases were?CgA-positive ,93 (98.9%) cases were Syn-positive and 27 (28.7%) cases were NSE- positive. Moreover, the mean Ki-67 index was (2.53±2.34)%,83 (88.3%) presented as grade?G1?tumors, while 11.7%were G2; The median follow-up time was 45 (10-131) months, and Kaplan-Meier analysis showed that lower WHO pathological grade and stage, tumor diameter <1cm, relatively young age group, CgA-negative had better OS and DFS (both P <0.05), while positive margin, Transendoscopic trap electrocoagulation, multiple tumors were associated with shorter DFS (P <0.05).In the multivariate analysis of the Cox proportional hazards model, CgA and tumor size affected OS, while resection margin and tumor size were independent prognostic factors associated with DFS.Conclusion:Tumor size, margin, and CgA are associated?with the outcomes of patients , Appropriate therapeutic strategies?should be developed for different tumor sizes,tumor sites,WHO grade and stage.