Abstract: ：ob＜x＞jective To study the ex＜x＞pression status of UNC-51-like kinase 1 (ULK1) , Raptor, and Rictor protein in different cervical tissues and to explore their significance. Methods 95 patients with cervical cancer, 30 patients with HSIL, 30 patients with LSIL and 30 patients with chronic cervicitis were selected and we used immunohistochemistry method to detect the ex＜x＞pression of ULK1,Raptor, and Rictor in the cervical tissue of each group, t he relationship between these three indicators and the clinicopathological features of cervical cancer was also analysed. Results The differences between ULK1 and Raptor and Rictor ex＜x＞pression in different cervical tissues were statistically significant.ULK1 was negatively correlated with the ex＜x＞pression levels of Raptor and Rictor in cervical cancer tissues (r = -0.640 、-0.687， 基金项目：江苏省妇幼保健协会科研项目（FYX202023）*通讯作者：电子邮箱：18052268119@189.cnboth P <0 ．05). ULK1, Raptor, and Rictor ex＜x＞pression correlated with the degree of tissue differentiation, FIGO stage, and tissue type （P＜0.05）. The overall survival of patients with negative ULK1 ex＜x＞pression was shorter than that of patients withpositive ex＜x＞pression, and the overall survival of patients with positive Raptor and Rictor ex＜x＞pression was shorter than that of patients with negative ex＜x＞pression （P＜0.05）. FIGO stage, tissue type, degree of tissue differentiation and positive ex＜x＞pression of ULK1, Raptor and Rictor were factors influencing the prognosis of patients with cervical cancer （both P＜0.05）. The degree of tissue differentiation, lymph node me＜x＞tastasis and Rictor were risk factors for the prognosis of cervical cancer, and ULK1 was an independent protective factor for the prognosis of cervical cancer （both P＜0.05）. Conclusion The ex＜x＞pression of ULK1, Raptor, and Rictor are associated with the occurrence, progression and prognosis of different cervical lesions and can be used as a valid predictor of cervical lesion progression and prognosis and a potential therapeutic target.