Abstract: Objective To explore the risk factors affecting the short-term prognosis of patients with unstable angina pectoris(UAP)after drug-coated balloon(DCB) therapy.Methods Patients with UAP who received DCB alone for coronary artery in situ lesions in the Affiliated Hospital of Xuzhou Medical University from June 2020 to June 2021 were enrolled. The major adverse cardiovascular events(MACE) after surgery were recorded, which was defined as hospitalization for recurrent angina, nonfatal acute myocardial infarction, unplanned secondary revascularization, acute heart failure, and cardiogenic death. According to the occurrence of MACE, they were divided into two groups: a MACE group and a non-MACE group. Then, logistic regression model analysis was constructed to analyze the risk factors for the occurrence of MACE, and a receiver operating characteristic curve(ROC) was plotted to assess its predictive value for the occurrence of MACE.Results A total of 256 patients were included in the current study, with an average follow-up time of(6.2±2.8) months and 33(12.89%) cases of MACE. The MACE group presented remarkable increases in lipoprotein a Lp(a), glycosylated hemoglobin(HbA1c) levels and 3-branch lesions than the non-MACE group(P<0.05). The binary logistic regression analysis suggested that Lp(a), HbA1c and 3-branch lesions were the independent risk factors for the occurrence of MACE. According to ROC curve analysis, the area under the ROC curve for Lp(a) and HbA1c was greater than 0.7, with good sensitivity(93.9%) and specificity(58.4%) when used in combination.Conclusions High Lp(a) and HbA1c levels are the independent risk factors for the short-term development of MACE in UAP patients after DCB, with certain predictive value for prognosis.