Abstract: Objective To assess the effectiveness and safety of ciprofol in patients undergoing hysteroscopic surgery.Methods A total of 136 patients who underwent hysteroscopic surgery in the First People's Hospital of Yancheng from May 2022 to July 2022 were selected. They were randomly divided into two groups(n=68): a propofol group and a ciprofol group. Both groups were compared for the success rate of hysteroscopic surgery, the time of recovery, the time of intraoperative additional dose, the total dose of remifentanil, the depth of sedation, anesthesia satisfaction, and safety.Results The success rate of hysteroscopic surgery was 100% in both groups. Compared with the propofol group, the ciprofol group showed decreases in the time of intraoperative additional dose(P<0.05), increases in the time of recovery(P<0.05), but improvement in satisfaction scores(P<0.05). The incidences of injection pain and respiratory depression in the ciprofol group were lower than those in the propofol group(all P<0.05).Conclusions Compared with propofol, cyclopofol exerts effect on the sedation and anesthesia of patients undergoing hysteroscopic surgery, which is not inferior to propofol, with less adverse reactions, which is worthy of clinical promotion.