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    赵塞, 邵永, 张丽娜, 董圆, 石林, 赵益明, 王建. 抗人平足蛋白单克隆抗体在结直肠癌中的临床应用研究[J]. 徐州医科大学学报, 2023, 43(3): 214-218. DOI: 10.3969/j.issn.2096-3882.2023.03.012
    引用本文: 赵塞, 邵永, 张丽娜, 董圆, 石林, 赵益明, 王建. 抗人平足蛋白单克隆抗体在结直肠癌中的临床应用研究[J]. 徐州医科大学学报, 2023, 43(3): 214-218. DOI: 10.3969/j.issn.2096-3882.2023.03.012
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    ZHAO Sai, SHAO Yong, ZHANG Lina, DONG Yuan, SHI Lin, ZHAO Yiming, WANG Jian. Clinical application of anti-human podoplanin monoclonal antibodies in colorectal cancer[J]. Journal of Xuzhou Medical University, 2023, 43(3): 214-218. DOI: 10.3969/j.issn.2096-3882.2023.03.012
    Citation: ZHAO Sai, SHAO Yong, ZHANG Lina, DONG Yuan, SHI Lin, ZHAO Yiming, WANG Jian. Clinical application of anti-human podoplanin monoclonal antibodies in colorectal cancer[J]. Journal of Xuzhou Medical University, 2023, 43(3): 214-218. DOI: 10.3969/j.issn.2096-3882.2023.03.012
    shu

    抗人平足蛋白单克隆抗体在结直肠癌中的临床应用研究

    Clinical application of anti-human podoplanin monoclonal antibodies in colorectal cancer

      摘要
    • 摘要: 目的 应用单克隆抗体SZ168探讨平足蛋白(PDPN)在结直肠癌组织中的表达及与临床病理参数和预后的关系。方法 通过免疫组化(单克隆抗体SZ168作为一抗)检测结直肠癌及癌旁组织中PDPN的表达水平差异,利用TCGA数据库对结直肠癌中PDPN表达及预后进行分析。结果 免疫组化检测显示PDPN在结直肠癌组织中高表达,在癌旁组织中低表达,且结直肠癌患者PDPN高表达和低表达组淋巴转移和肿瘤远处转移的差异有统计学意义(P<0.05),年龄、性别、T分期的差异无统计学意义(P>0.05);生存分析显示PDPN高表达与低表达的结肠癌患者预后差异无统计学意义(P>0.05)。结论 单克隆抗体SZ168可应用于结直肠癌免疫组化中PDPN的检测,检测阳性率较高,PDPN检测在结直肠癌的临床诊断中具有一定的价值。

       

      Abstract: Objective To investigate the expression of podoplanin(PDPN) in colorectal cancer tissues and its relationship with clinicopathological parameters and prognosis, using monoclonal antibody SZ168.Methods The difference of PDPN levels in colorectal cancer and adjacent tissues were detected by immunohistochemistry. The expression of PDPN in colorectal cancer and prognosis were analyzed using TCGA database.Results Immunohistochemical detection showed high expression of PDPN in colorectal cancer tissues and low expression in adjacent tissues. Significant differences were found in lymphatic metastasis and distant tumor metastasis between the high and low expression of PDPN groups(P<0.05), but no difference was found in age, sex and T stage(P>0.05). Survival analysis showed no statistical difference in colon cancer patients with high and low expression of PDPN(P>0.05).Conclusions The monoclonal antibody SZ168 can be used to detect PDPN in colorectal cancer by immunohistochemistry, with a high positive rate. PDPN detection has certain value in the clinical diagnosis of colorectal cancer.

       

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