Abstract: A female patient, age 48 years, was admitted to our hospital due to "fatigue and anorexia for one week and oliguria for two days". After drinking alcohol, she presented hematuria, proteinuria, leukocyturia, oliguria, and renal insufficiency. According to renal biopsy, acute renal tubule-interstitial injury and oxalate nephropathy were detected. She was then treated with glucocorticoid immunosuppressive agents, and received temporary hemodialysis, fluid hydration and symptomatic treatment. Then, her urine output was recovered, hematuria and proteinuria turned negative, and renal function returned to normal.