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    夏建锋, 纪建兵, 吴霞, 缪伶伶, 陈晚琴. 孤独症谱系障碍患儿维生素D及叶酸水平与病情程度的相关性研究[J]. 徐州医科大学学报, 2023, 43(6): 459-462. DOI: 10.3969/j.issn.2096-3882.2023.06.012
    引用本文: 夏建锋, 纪建兵, 吴霞, 缪伶伶, 陈晚琴. 孤独症谱系障碍患儿维生素D及叶酸水平与病情程度的相关性研究[J]. 徐州医科大学学报, 2023, 43(6): 459-462. DOI: 10.3969/j.issn.2096-3882.2023.06.012
    shu
    XIA Jianfeng, JI Jianbing, WU Xia, MIAO Lingling, CHEN Wanqin. Correlation between vitamin D and folic acid levels and the severity of autism spectrum disorder in children[J]. Journal of Xuzhou Medical University, 2023, 43(6): 459-462. DOI: 10.3969/j.issn.2096-3882.2023.06.012
    Citation: XIA Jianfeng, JI Jianbing, WU Xia, MIAO Lingling, CHEN Wanqin. Correlation between vitamin D and folic acid levels and the severity of autism spectrum disorder in children[J]. Journal of Xuzhou Medical University, 2023, 43(6): 459-462. DOI: 10.3969/j.issn.2096-3882.2023.06.012
    shu

    孤独症谱系障碍患儿维生素D及叶酸水平与病情程度的相关性研究

    Correlation between vitamin D and folic acid levels and the severity of autism spectrum disorder in children

      摘要
    • 摘要: 目的 分析维生素D(VitD)及叶酸水平与孤独症谱系障碍(ASD)患儿病情程度的相关性。方法 选择2017年3月-2022年3月如皋市人民医院确诊为ASD的55例患儿作为ASD组,同时选择于我院同期体检的55例健康儿童作为对照组。清晨空腹采集受试者外周静脉血检测血清25-羟基维生素D325(OH) D3及叶酸水平。采用儿童孤独症评定量表(CARS) 评估ASD患儿病情程度,采用Pearson相关分析ASD患儿血清25(OH) D3及叶酸与CARS评分的关系,并通过受试者工作特征曲线(ROC)分析血清25(OH)D3与ASD患儿病情危重程度的关系。结果 ASD组患儿血清中25(OH) D3及叶酸水平明显低于对照组(P<0.05),2组VitD不足率及叶酸缺乏率比较差异均有统计学意义(P<0.05)。55例ASD患儿经CARS量表评估确定重度19例,轻中度36例,重度患儿VitD缺乏率明显高于轻中度患儿(P<0.05)。Pearson相关分析显示ASD患儿25(OH) D3与CARS评分呈负相关(r=-0.606,P=0.000)。ROC曲线分析显示当25(OH)D3取15.8 μg/L(最佳截点值)时,重度ASD患儿的敏感度、特异度分别为73.80%、91.4%,曲线下面积为0.85。结论 ASD患儿体内血清25(OH) D3及叶酸水平均明显降低,且ASD与VitD存在相关性。25(OH) D3可作为预测重度ASD患儿病情程度的辅助指标。

       

      Abstract: Objective To analyze the correlation between vitamin D(VitD) and folic acid levels and the severity of autism spectrum disorder (ASD) in children.Methods A total of 55 children who were admitted to Rugao People's Hospital from March 2017 to March 2022 and diagnosed with ASD were selected as an ASD group. Meanwhile, another 55 healthy children who underwent physical examination in our hospital during the same period were selected as a control group. Their fasting blood samples were collected from the peripheral veins in the morning to detect the levels of serum 25(OH)D3 and folic acid levels. The severity of ASD in these children was assessed using the Children's Autism Rating Scale (CARS). Pearson correlation analysis was conducted to analyze the relationship between serum 25(OH)D3 and folic acid and CARS scores in ASD children. A receiver operating characteristic curve was plotted to analyze the relationship between serum 25(OH)D3 and the severity of ASD children.Results The levels of serum 25(OH)D3 and folic acid in the ASD group were significantly lower than those in the control group (all P<0.05). In addition, there were statistical differences in VitD deficiency rate and folate deficiency rate between the two groups (P<0.05). According to the CARS, there were 19 severe cases and 36 mild to moderate cases among the 55 ASD children. The VitD deficiency rate in severe children was significantly higher than that in mild to moderate children (P<0.05). Pearson correlation analysis showed that there was a strong negative correlation between 25(OH)D3 and CARS scores (r=-0.606, P=0.000). ROC curve analysis showed that when 25(OH)D3 was 15.8 μg/L (the optimal cut-off value), the sensitivity and specificity of severe ASD children were 73.80% and 91.4%, respectively, with the area under the curve of 0.85.Conclusions Serum 25(OH) D3 and folic acid levels in ASD children are significantly reduced. ASD is correlated with VitD. 25(OH) D3 can be used as an auxiliary indicator to predict the severity of children with severe ASD.

       

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