Abstract: Objective To explore the effect of Kangfuxin liquid combined with azithromycin on postoperative nasal ventilation function and olfactory function in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).Methods A total of 118 patients with CRSwNP who underwent functional endoscopic sinus surgery in Beijing Aerospace General Hospital were selected. They were divided into two groups (n=59):a control group and a combined group. The control group was treated with azithromycin, while the combined group was given Kangfuxin liquid combined with azithromycin. Both groups were compared for clinical efficacy, nasal ventilation function nasal minimal cross-sectional area (NMCA), nasal cavity volume (NCV), and distance of the minimal cross-sectional area to the nostril (DCAN), olfactory function (T&T standard olfactory test method), nasal cavity mucosal inflammation indicators interleukin-6 (IL-6), and mucin MUC5AC, nasal mucociliary clearance function (mucociliary clearance rate, mucociliary clearance speed, and saccharin clearance time) and adverse reactions.Results The combined group showed a higher total effective rate (94.92%) than the control group (81.36%) (P<0.05). Compared with those before treatment, both groups showed remarkable increases in NCV, NMCA, and mucociliary clearance rates after treatment (P<0.05), where significant increases were seen in the combined group, compared with those in the control group (P<0.05). After treatment, both groups presented remarkable decreases in DCAN, post-olfactory function score, mucociliary clearance rate, saccharin clearance time, MUC5AC, and IL-6 levels (P<0.05), where significant decreases were seen in the combined group, compared with those in the control group (P<0.05). There were no adverse reactions such as abnormal liver and kidney function, vomiting and nausea in both groups.Conclusions Kangfuxin liquid combined with azithromycin is safe and effective for the treatment of CRSwNP patients, which can effectively improve nasal ciliary clearance function, nasal ventilation function and olfactory function, reduce local inflammatory response.