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    刘亚, 戴春, 杨晶, 邱晓楠. 血清抗磷脂酶A2受体抗体在特发性膜性肾病中的临床意义[J]. 徐州医科大学学报, 2017, 37(9): 571-573.
    引用本文: 刘亚, 戴春, 杨晶, 邱晓楠. 血清抗磷脂酶A2受体抗体在特发性膜性肾病中的临床意义[J]. 徐州医科大学学报, 2017, 37(9): 571-573.
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    LIU Ya, DAI Chun, YANG Jing, QIU Xiaonan. Clinical significance of serum anti-phospholipase A2 receptor antibodies in idiopathic membranous nephropathy[J]. Journal of Xuzhou Medical University, 2017, 37(9): 571-573.
    Citation: LIU Ya, DAI Chun, YANG Jing, QIU Xiaonan. Clinical significance of serum anti-phospholipase A2 receptor antibodies in idiopathic membranous nephropathy[J]. Journal of Xuzhou Medical University, 2017, 37(9): 571-573.
    shu

    血清抗磷脂酶A2受体抗体在特发性膜性肾病中的临床意义

    Clinical significance of serum anti-phospholipase A2 receptor antibodies in idiopathic membranous nephropathy

      摘要
    • 摘要: 目的检测特发性膜性肾病（idiopathic membranous nephropathy，IMN）患者血清抗磷脂酶A2受体（phospholipase A2 receptor，PLA2R）抗体水平，探讨抗PLA2R抗体对IMN诊断和疾病评估的意义。方法选取2016年1月—2017年6月于徐州医科大学附属医院肾内科行肾穿刺活检术的初发肾病综合征患者62例，分为IMN组30例和非IMN组32例，采用酶联免疫吸附法检测血清抗PLA2R抗体，并收集相关临床资料进行统计分析。结果IMN组患者抗PLA2R抗体阳性率为83.33%（25/30），非IMN组抗PLA2R抗体阳性率为9.38%（3/32）,2组间的差异有统计学意义(P<0.01)。IMN组血清抗PLA2R抗体水平与24 h尿蛋白总量呈正相关，与血清白蛋白水平呈负相关。结论血清抗PLA2R抗体检测作为无创性检测手段对于特发性膜性肾病的诊断和疾病评估具有重要意义。

       

      Abstract: ObjectiveTo investigate the level of serum anti-phospholipase A2 receptor antibody (anti-PLA2R Ab) in patients with idiopathic membranous nephropathy (IMN) and evaluate the diagnosis of IMN using anti-PLA2R Ab. MethodsA total of 62 patients who received renal biopsy and was diagnosed as primary nephrotic syndrome from January 2016 to June 2017 in our department were enrolled. They were divided into an IMN group (n=30) and a non-IMN group (n=32). The levels of serum anti-PLA2R Ab were detected by enzyme-linked immunosorbent assay. Related clinical data were collected for statistical analysis. ResultsThe positive anti-PLA2R Ab rate was 83.33% (25/30) in the IMN group, and 9.38% (3/32) in the non-IMN group. The level of serum anti-PLA2R Ab was positively correlated with 24 hour urine protein, but negatively correlated with serum albumin levels. ConclusionSerum anti-PLA2R Ab level can be adopted for diagnosis and evaluation of IMN.

       

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