石杉碱甲对氯胺酮致小鼠记忆障碍的影响

顾毓庭; 赵光; 王雪薇; 尤悦; 王佳奇; 熊伟; 刁寒; 郭忠民; 王丹

石杉碱甲对氯胺酮致小鼠记忆障碍的影响

Effects of huperzine A on ketamine-induced memory impairment in mice

摘要

摘要: 目的研究石杉碱甲（huperzine A）对氯胺酮（ketamine）所致小鼠记忆障碍的影响。方法将小鼠随机分为3组：生理盐水组（NS组），氯胺酮35 mg·kg-1组（K组）和石杉碱甲0.2 mg·kg-1+氯胺酮35 mg·kg-1组（HK组），每组10只。在避暗实验中，小鼠腹腔注射氯胺酮建立记忆障碍模型，观察石杉碱甲对记忆障碍小鼠潜伏期和错误次数的影响。结果与NS组相比，K组和HK组的错误次数明显增多，潜伏期明显缩短（P均<0.01）；与K组相比，HK组错误次数明显减少，潜伏期明显延长（P均< 0.01）。结论石杉碱甲能部分改善氯胺酮所致的小鼠记忆障碍。

Abstract: ObjectiveTo investigate the effects of huperzine A on ketamine-induced memory impairment in mice. MethodsMice were randomly divided into three groups (n=10): a normal saline (NS) group, a 35 mg·kg-1 ketamine (K) group and a 0.2 mg·kg-1 huperzine A+ 35 mg·kg-1 ketamine (HK) group. A mouse model of memory impairment was established through intraperitoneal injection of ketamine. Then, the effects of huperzine A on the latency and number of errors were observed in the step-through test. ResultsCompared with the NS group, the K group and the HK group presented a remarkably higher number of errors and shortened latency (P<0.01). Compared with the K group, the HK group showed a markedly less number of errors and extended latency (P<0.01). ConclusionsHuperzine A can partially improve ketamine- induced memory impairment in mice.

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