Abstract: ObjectiveTo compare the levels of cardiactroponin I (cTnI) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) before and after perventricular device closure (PDC) or cardiopulmonary bypass (CPB) in patients with ventricular septal defect (VSD), and discuss the characteristics of cTnI and NT-proBNP to reflect cardiac injury, and the advantages of PDC through VSD. MethodsA total of 52 child patients with VSD who were suitable for PDC after evaluation by thoracic echocardiography. Then, 32 child patients received PDC, while another 20 received CPB. The levels of serum cTnI and NT-proBNP were detected immediately, 6 h, 12 h, 24 h, and 2 d, 4 d, and 8 d after operation. ResultsThe levels of cTnI in the two groups reached the peak 6 h after operation, which were then gradually decreased. The PDC group showed lower levels of cTnI than the CPB group at all time points except 8 days after operation (P＜0.05). The levels of NT-proBNP reached the peak at 24 h for the PDC group and 12 h for the CPB group after operation, and were then gradually decreased. The PDC group showed lower levels of NT-proBNP than the CPB group at 6 h, 12 h, 24 h, and 2 d after operation (P＜0.05). ConclusionsCompared with CPB, less cardiac damage is found in VSD patients after PDC. Compared with NT-proBNP, cTnI is more sensitive to evaluate cardiac damage.