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    刘洪锋, 孙波, 李志, 李迎新. E-cadherin和 β-catenin在胸腺瘤侵袭转移过程中的表达及意义[J]. 徐州医科大学学报, 2018, 38(7): 449-453.
    引用本文: 刘洪锋, 孙波, 李志, 李迎新. E-cadherin和 β-catenin在胸腺瘤侵袭转移过程中的表达及意义[J]. 徐州医科大学学报, 2018, 38(7): 449-453.
    shu
    Department of thoracic surgery, the first people’’’’s Hospital of Jining[J]. Journal of Xuzhou Medical University, 2018, 38(7): 449-453.
    Citation: Department of thoracic surgery, the first people’’’’s Hospital of Jining[J]. Journal of Xuzhou Medical University, 2018, 38(7): 449-453.
    shu

    E-cadherin和 β-catenin在胸腺瘤侵袭转移过程中的表达及意义

    Department of thoracic surgery, the first people’’’’s Hospital of Jining

      摘要
    • 摘要: 目的:探讨E-cadherin和 β-catenin 在胸腺瘤侵袭转移过程中的表达及意义。方法:应用β-catenin与E-cadherin单克隆抗体对87例胸腺上皮性肿瘤组织石蜡切片标本做免疫组化PV-6000检测，并观察两者的表达与患者胸腺瘤侵袭和转移之间的关系。结果:E-cadherin和β-catenin在胸腺瘤WHO分型和Masaoka分期中的表达情况：E-cadherin在上皮性胸腺肿瘤中的表达情况：按胸腺瘤WHO分型其在A、AB、B1、B2、B3、C型中的表达分别为44.4%、37.5%、41.2%、47.1%、58.3%和31.3%，其差异不具有统计学意义（χ2=2.394，P>0.05）。按Masaoka系统的I期、II期、III-IV期分期中，阳性表达率随随肿瘤分期增高而降低，分别为60%、19.2%和18.2%，其组间差异具有统计学意义（χ2=15.469，P<0.05）。 β-catenin在胸腺瘤中的情况：其在WHO分型中的表达情况A、AB、B1、B2、B3、C型中的表达分别为33.3%、25%、29.4%、23.5%、33.3%和37.5%，其差异不具有统计学意义（χ2=1.074，P>0.05）。在Masaoka系统I期、II期、III-IV期分期中，高阳性表达率分别为37.5%,76.9%和90.9% ，表达率随着肿瘤分期增高而降低，其组间差异具有统计学意义（χ2=24.625，P<0.05）

       

      Abstract: Objective: To investigate the expression and significance of E-cadherin and β-catenin in the invasion and metastasis of thymoma. Methods: β-catenin and E-cadherin monoclonal antibody was used to examined thymic epithelial tumor tissue paraffin sections of 87 cases by the method of immunohistochemistry PV-6000 and the relationship between the expression and the invasion and metastasis of thymoma was observed. Results The expression of E-cadherin and β-catenin in the classification of thymoma according to WHO and Masaoka: The expression of E-cadherin in epithelial thymoma, and the expression in A, AB, B1, B2, B3 and C were 44.4%, 37.5%, 41.2%, 47.1%, 58.3% and 31.3%, respectively. There was no statistically significance between the difference. (χ2 = 2.394, P> 0.05). According to the Masaoka system stage I, II and III-IV, the positive expression rate was decreased with the increase of tumor stage and the rates were 60%, 19.2% and 18.2% respectively. The difference between the two groups was statistically significant (χ2 = 15.469, P <0.05). The expression of β-catenin in thymoma: The expression in WHO type A, AB, B1, B2, B3 and C were 33.3%, 25%, 29.4%, 23.5% and 33.3% and 37.5%, respectively. The difference was not statistically significant (χ2 = 1.074, P> 0.05). The positive expression rates of Masaoka system in stages I, II and III-IV with the increase of tumor staging were 37.5%, 76.9% and 90.9%, respectively. The differences between the two groups were statistically significant (χ2 = 24.625, P <0.05)

       

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