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    刘爽, 董碧蓉. 奥氮平联合多奈哌齐治疗方案对伴有精神行为症状的阿尔茨海默病治疗的有效性及安全性Meta分析[J]. 徐州医科大学学报, 2018, 38(6): 385-388.
    引用本文: 刘爽, 董碧蓉. 奥氮平联合多奈哌齐治疗方案对伴有精神行为症状的阿尔茨海默病治疗的有效性及安全性Meta分析[J]. 徐州医科大学学报, 2018, 38(6): 385-388.
    shu
    Meta analysis of olanzapine combined with donepezil on the treatment of Alzheimer’’s disease[J]. Journal of Xuzhou Medical University, 2018, 38(6): 385-388.
    Citation: Meta analysis of olanzapine combined with donepezil on the treatment of Alzheimer’’s disease[J]. Journal of Xuzhou Medical University, 2018, 38(6): 385-388.
    shu

    奥氮平联合多奈哌齐治疗方案对伴有精神行为症状的阿尔茨海默病治疗的有效性及安全性Meta分析

    Meta analysis of olanzapine combined with donepezil on the treatment of Alzheimer’’s disease

      摘要
    • 摘要: 目的：系统评价奥氮平联合多奈哌齐治疗阿尔茨海默病的总体疗效和安全性。方法：计算机检索PubMed、EMbase、The Cochrane Library、中国知网（CNKI）、中国生物医学文献数据库(CBM)、维普(VIP)和万方数据库，搜集应用奥氮平联合多奈哌齐治疗阿尔茨海默病的相关临床研究文献，检索时限从建库至2017年9月，由两位评价者独立筛选文献、提取资料并评价纳入研究的偏倚风险后，采用Rev Man 5.3软件进行Meta分析。结果：筛选出质量评价合格文献共6篇。奥氮平联合多奈哌齐与单独给予奥氮平相比，能够明显增加阿尔茨海默病患者的治疗总有效率和MMSE评分，且差异具有统计学意义（P<0.05）。结论：应用奥氮平联合多奈哌齐治疗方案能提高老年阿尔茨海默病患者的疗效。

       

      Abstract: Objective To systematically evaluate the efficacy and safety of olanzapine combined with donepezil on the treatment of Alzheimer’s disease. Methods The databases PubMed, EMbase, The CochraneLibrary, CNKI, VIP and WanFang Data were searched by computar, and randomized controlled trials (RCTs) about olanzapine with donepezil treatment for Alzheimer’s disease from inception to September 2017 were collected. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed using RevMan 5.3 software . Results A total of 6 literatures of quality evaluation were selected. Treatment program of olanzapine with donepezil could significantly increase the total efficiency and MMSE score of patients with Alzheimer’s disease than that of alone olanzapine treatment, and the difference was statistically significant (P < 0.05). Conclusion The olanzapine and donepezil can improve the curative effect of elderly patients with Alzheimer’s disease.

       

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