高级检索
    张月蔓, 张鋆杰, 武玉清, 强梦霜, 毛从莉, 郭磊, 陈青. 依托咪酯对创伤后应激障碍（PTSD）小鼠焦虑状态和认知功能的影响[J]. 徐州医科大学学报, 2018, 38(4): 240-243.
    引用本文: 张月蔓, 张鋆杰, 武玉清, 强梦霜, 毛从莉, 郭磊, 陈青. 依托咪酯对创伤后应激障碍（PTSD）小鼠焦虑状态和认知功能的影响[J]. 徐州医科大学学报, 2018, 38(4): 240-243.
    shu
    Effects of etomidate on the state of anxiety and cognitive function in mice with PTSD[J]. Journal of Xuzhou Medical University, 2018, 38(4): 240-243.
    Citation: Effects of etomidate on the state of anxiety and cognitive function in mice with PTSD[J]. Journal of Xuzhou Medical University, 2018, 38(4): 240-243.
    shu

    依托咪酯对创伤后应激障碍（PTSD）小鼠焦虑状态和认知功能的影响

    Effects of etomidate on the state of anxiety and cognitive function in mice with PTSD

      摘要
    • 摘要: 目的 探讨依托咪酯对创伤后应激障碍(PTSD)小鼠焦虑状态和认知功能的影响。方法 将小鼠随机分为五组：对照组(C组)、PTSD模型组(P组)和依托咪酯3 、6、12mg／kg组(E1、E2、E3组)，通过条件性恐惧实验测定小鼠的恐惧记忆，旷场实验和高架十字迷宫测定小鼠的焦虑状态，水迷宫实验测定小鼠的学习记忆能力。结果 在条件性恐惧实验中，与C组比较，P组僵住时间明显增加；与P组比较，E3组僵住时间明显增加（P均<0.05）。在旷场中，与C组比较，P组中央格停留时间明显减少；与P组比较，E3组中央格停留时间明显增加（P均<0.01）。在高架实验中，与C组比较，P组开环时间比例明显减少；与P组比较，E3组开环时间比例明显增加（P均<0.05）。在水迷宫实验中，与C组比较，P组潜伏期明显增加及目标象限停留时间明显减少；与P组比较，E组潜伏期明显减少及目标象限停留时间明显增加（P均<0.05）。结论 依托咪酯可明显改善PTSD小鼠的焦虑状态，并增强学习记忆能力。

       

      Abstract: Objective To investigate the effects of etomidate on the state of anxiety and cognitive function in mice with PTSD. Methods Male SD mice were randomly divided into five groups: control group (group C), PTSD model group (group P) and etomidate groups of low, medium and high dose (groups E1, E2, E3; 3, 6 and 12 mg／kg). Fear memory in mice is evaluated by fear Condition (FC), locomotor activity by open field (OF). State of anxiety is elevated by plus maze (EPM), learning and memory by spatial learning and memory by Morris water maze (MWM). Results Compared with group C, the percentage of freezing time in the FC were significantly increased (P<0.05) in group P; Compared with group P, the percentage of freezing time in the FC were significantly decreased (P<0.05) in group E3. Compared with group C, the residence time in the central gird of the OF were significantly decreased (P<0.01) in group P; Compared with group P, the residence time in the central gird of the OF were significantly increased (P<0.01) in group E3. Compared with group C, the proportion of time in the open arm of the EPM were significantly decreased (P<0.05) in group P; Compared with group P, the proportion of time in the open arm of the EPM were significantly increased (P<0.05) in group E3. . Compared with group C, the latency in the MWM were significantly increased (P<0.05) and the proportion of time in the target quadrant of the MWM were significantly decreased (P<0.05) in group P; Compared with group P, the latency in the MWM were significantly decreased (P<0.05) and the proportion of time in the target quadrant of the MWM were significantly increased (P<0.05) in group E. Conclusion Etomidate can significantly improve anxiety, enhance the ability of learning memory in mice with PTSD.

       

      • HTML全文
      • 参考文献(0)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回