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    鱼敏逸, 朱仙艺, 张爱青, 陆晓羽, 龚向前, 甘卫华, 陈俊宇. hsa-miR-199b-5p靶基因预测及生物信息学分析[J]. 徐州医科大学学报, 2018, 38(6): 389-393.
    引用本文: 鱼敏逸, 朱仙艺, 张爱青, 陆晓羽, 龚向前, 甘卫华, 陈俊宇. hsa-miR-199b-5p靶基因预测及生物信息学分析[J]. 徐州医科大学学报, 2018, 38(6): 389-393.
    shu
    Target genes prediction and bioinformatics analysis of hsa-miR-199b-5p[J]. Journal of Xuzhou Medical University, 2018, 38(6): 389-393.
    Citation: Target genes prediction and bioinformatics analysis of hsa-miR-199b-5p[J]. Journal of Xuzhou Medical University, 2018, 38(6): 389-393.
    shu

    hsa-miR-199b-5p靶基因预测及生物信息学分析

    Target genes prediction and bioinformatics analysis of hsa-miR-199b-5p

      摘要
    • 摘要: 目的：初步论述miR-199b-5p的生物学功能。方法：首先我们应用miRbase、UCSC等数据库，对miR-199b-5p的序列进行了保守性分析；然后选择miranda、miRDB及TargetScan三个数据库预测hsa-miR-199b-5p的靶基因，取其交集；最后运用基因GO功能注释以及KEGG信号转导通路富集分析，探究miR-199b-5p靶基因可能相关的细胞功能和信号通路。结果：生物信息学分析发现，miR-199b-5p具有多种功能，其多个潜在靶基因涉及足细胞损伤发生、发展过程。结论：miR-199b-5p可能与慢性肾脏病（Chronic Kidney Disease，CKD）的发病机制相关，并为临床治疗提供了可能的潜在的新靶点。

       

      Abstract: Objective: To identify the potential biological function of hsa-miR-199b-5p. Methods：First and foremost, we used miRbase and UCSC databases to analyzed its conservation of the sequence. Secondly, we predicted the target genes of hsa-miR-199b-5p through Miranda, miRDB and TargetScan databases. Then we get the intersection of these predicted genes . In the end, by using GO and KEGG pathway analysis, we clarified the cell functions and signaling pathways which are regulated by hsa-miR-199b-5p target genes . Results: Given the bio-informatics data, we figured out that hsa-miR-199b-5p may have a wide range of functions. Also, some potential target genes of hsa-miR-199b-5p might be involved in the initiation and development of podocyte injury. Conclusion: Hsa-miR-199b-5p might be related to the pathogenesis of CKD. Thus,it might provide the clinical therapy with a potential target to CKD

       

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