Abstract: Objective: To explore the role of serum C-reactive protein/albumin ratio in predicting the prognosis of patients with acute pancreatitis. Methods: Retrospective analysis of 258 cases with acute pancreatitis in our hospital from January 201 0 to January 201 8. At the same time, the age, gender and other matched normal health examination patients were selected as the control. Extraction the data of gender, age, and white blood cell count, neutrophil count, lymphocyte count, procalcitonin, C-reactive protein, serum albumin, and calculation of neutrophils/lymphocyte ratio, C-reactive protein/albumin ratio. S tatistical analysis was used to discuss the relationship of neutrophils/lymphocyte ratio, Procalcitonin, C-reactive protein, and serum C-reactive protein/albumin ratio with disease severity and prognosis of patients with acute pancreatitis. Results: Compared with healthy controls, white blood cell count, neutrophil count, neutrophil/lymphocyte ratio, Procalcitonin, C-reactive protein and serum C-reactive protein/albumin ratio in patients with acute pancreatitis were significantly higher than normal healthy controls (P < 0.05), however, lymphocyte count was significantly lower (P < 0.05). Neutrophils/lymphocyte ratio , procalcitonin, C-reactive, serum C-reactive protein/albumin ratio was higher in serious patients or patients with systemic inflammatory response syndrome or dead in hospital (P < 0.05). Compared with neutrophils/lymphocyte ratio, Procalcitonin, C-reactive protein, the specificity, sensitivity, and Youden index of serum C-reactive protein/albumin ratio in predicting the prognosis of patients with acute pancreatitis were higher. Conclusion: The serum c-reactive protein/albumin ratio could predict the prognosis of patients with acute pancreatitis. The specificity and sensitivity were higher than neutrophils/lymphocyte ratio, Procalcitonin and C-reactive protein, which were commonly used