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    刘振杰. 巨噬细胞移动抑制因子在幽门螺杆菌相关胃粘膜炎症中的表达[J]. 徐州医科大学学报, 2020, 40(4): 265-267.
    引用本文: 刘振杰. 巨噬细胞移动抑制因子在幽门螺杆菌相关胃粘膜炎症中的表达[J]. 徐州医科大学学报, 2020, 40(4): 265-267.
    shu
    Expression of macrophage migration inhibitory factor in Helicobacter pylori associated gastric mucositis[J]. Journal of Xuzhou Medical University, 2020, 40(4): 265-267.
    Citation: Expression of macrophage migration inhibitory factor in Helicobacter pylori associated gastric mucositis[J]. Journal of Xuzhou Medical University, 2020, 40(4): 265-267.
    shu

    巨噬细胞移动抑制因子在幽门螺杆菌相关胃粘膜炎症中的表达

    Expression of macrophage migration inhibitory factor in Helicobacter pylori associated gastric mucositis

      摘要
    • 摘要: 目的：分析在幽门螺杆菌（Hp）相关胃粘膜炎症中巨噬细胞移动抑制因子（MIF）的表达。方法：选取我院2017年03月～2018年05月收治的慢性胃炎患者50例进行研究，根据是否发生hp感染，将其分为Hp阳性组（34例）、Hp阴性组（16例），并选择同期进行健康检查且检查结果为胃黏膜组织正常的24例患者（对照组）。收集所有患者的临床资料，并对其MIF、Hp等指标进行检测。观察并比较各组患者的MIF水平、阳性情况，MIF mRNA表达、阳性情况以及Hp相关胃黏膜炎症程度与MIF表达之间的关系。结果：Hp阳性组、Hp阴性组的MIF水平、MIF阳性率、MIF mRNA表达、MIF mRNA阳性率均显著高于对照组；Hp阳性组的MIF水平、MIF阳性率、MIF mRNA表达、MIF mRNA阳性率均显著高于Hp阴性组；Hp阳性患者中，轻度慢性炎症、中度慢性炎症MIF mRNA表达均显著低于重度慢性炎症；轻度慢性炎症MIF mRNA表达均显著低于中度慢性炎症，差异具有统计学意义(P＜0.05)。结论：在Hp感染相关胃粘膜炎症中，MIF水平、MIF mRNA表达均有所增加，且随着炎症程度的不断加重也随之升高。

       

      Abstract: Objective: to analyze the expression of macrophage migration inhibitory factor (MIF) in Helicobacter pylori (Hp) associated gastric mucositis. Methods: 50 patients with chronic gastritis were selected from 03 months to 05 months of 2018 from 2017 to 2018. According to whether HP infection occurred, the patients were divided into Hp positive group (34 cases) and Hp negative group (16 cases), and 24 patients (control group) were selected for the same period of health examination and the results were normal in the gastric mucosa. The clinical data of all patients were collected, and their MIF, Hp and other indicators were detected. The MIF level, positive status, MIF mRNA expression, positive status and the relationship between the degree of Hp related gastric mucosa inflammation and the expression of MIF were observed and compared. Results: the MIF level, the positive rate of MIF, the expression of MIF mRNA and the positive rate of MIF mRNA in the Hp positive group and the Hp negative group were significantly higher than those in the control group, and the MIF level, MIF positive rate, MIF expression and positive rate in the Hp positive group were significantly higher than those in the negative group. The expression of MIF mRNA in mild chronic inflammation was significantly lower than that in moderate chronic inflammation, and the difference was statistically significant (P < 0.05). Conclusion: in Hp infection associated gastric mucositis, MIF level and MIF mRNA expression increased, and the severity of inflammation increased

       

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