原发性肾上腺淋巴瘤7例临床分析

杨晶晶; 桑威; 闫冬梅; 宋旭光; 田宇; 李庆; 周航; 徐开林

原发性肾上腺淋巴瘤7例临床分析

Clinical analysis of 7 cases of primary adrenal lymphoma

摘要

摘要: 目的探讨原发性肾上腺淋巴瘤（ PAL）患者的临床特征、治疗情况及预后。方法回顾性分析7例PAL患者，包括弥漫大B细胞淋巴瘤（DLBCL）6例，NK/T细胞淋巴瘤1例的临床资料。结果 7例患者中位年龄为63（39～76）岁，男6例，女1例；双侧发病5例，单侧发病2例；7例患者均接受单侧肾上腺肿块切除术。DLBCL组，5例化疗，2例（40%）完全缓解（CR），1例（20%）部分缓解（PR），总反应率（ORR）为60%；NK/T细胞淋巴瘤组采用以左旋门冬酰胺酶为主的方案化疗联合放疗，患者达CR。4例DLBCL患者分别生存0.2、2.7、2.8、9.6个月后死亡。结论 PAL很罕见，恶性度高，预后差，多以DLBCL最常见，好发于老年男性，双侧多见，治疗上以联合化疗为主。

Abstract: Objective To explore the clinical characteristics, treatment and prognosis of patients with primary adrenal lymphoma ( PAL). Methods The clinical data of 7 cases of PAL were retrospectively analyzed, including 6 cases of diffuse large B-cell lymphoma (DLBCL) and 1 case of NK/T-cell lymphoma. Results The median age of 7 patients was 63(39～76) years , 6 cases were male，1 case was female．2 cases presented with unilateral and 5 cases with bilateral masses．Seven patients underwent unilateral adrenalectomy. In the DLBCL group, 5 cases received chemotherapy, 2 cases (40%) had complete remission (CR), 1 case (20%) had partial remission (PR), and the overall response rate (ORR) was 60% . NK/T cell lymphoma group treated with L-asparaginase based chemotherapy combined with radiotherapy, and the patient achieved CR. 4 cases of DLBCL died with a follow-up survival time of 0.2, 2.7, 2.8, and 9.6 months, respectively. Conclusion PAL is rare with high malignancy and poor prognosis. DLBCL is the most common type of PAL, predominantly occurring in elderly males and bilaterally. Combined chemotherapy is the main treatment for PAL

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