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    陆远. 基于X射线冠状动脉造影的无创血流储备分数在冠心病介入诊治中的应用探索[J]. 徐州医科大学学报, 2019, 39(11): 792-796.
    引用本文: 陆远. 基于X射线冠状动脉造影的无创血流储备分数在冠心病介入诊治中的应用探索[J]. 徐州医科大学学报, 2019, 39(11): 792-796.
    shu
    Noninvasive fractional flow reserve based on X-ray coronary angiography in interventional diagnosis and treatment of coronary artery disease[J]. Journal of Xuzhou Medical University, 2019, 39(11): 792-796.
    Citation: Noninvasive fractional flow reserve based on X-ray coronary angiography in interventional diagnosis and treatment of coronary artery disease[J]. Journal of Xuzhou Medical University, 2019, 39(11): 792-796.
    shu

    基于X射线冠状动脉造影的无创血流储备分数在冠心病介入诊治中的应用探索

    Noninvasive fractional flow reserve based on X-ray coronary angiography in interventional diagnosis and treatment of coronary artery disease

      摘要
    • 摘要: 目的 初步探究基于X射线冠状动脉造影的全自动冠状动脉血流储备分数（CAFFR）和传统有创血流储备分数（FFR）相比在冠心病介入诊治方面的应用价值。方法 纳入2012年01月至2014年12月于我院接受冠状动脉造影血管成像（CAG）及FFR 检查的可疑或确诊冠心病的病人38 例，其中男23例、女15 例，平均年龄（60.4±8.2）岁。采用基于X射线冠状动脉造影图像的全自动冠状动脉血流储备分数计算方法进行FFR 值测定，以有创性FFR 结果作为金标准，分析比较CAFFR在冠心病病人介入诊治中的准确度。采用Pearson 相关性检验及Bland-Altman 方法比较CAFFR与FFR 的诊断相关性及一致性。结果 以病变血管为分析单位，FFR＞0.8为26，CAFFR＞0.8为25，FFR≤0.8为16，CAFFR≤0.8为7，CAFFR与FFR 的诊断一致性（95%，CI 为-0.09～0.17）及相关性良好（r=0.661，P＜0.001）。结论 CAFFR在于冠心病病人介入诊治中具有良好的临床应用价值。

       

      Abstract: Objective: The application value of CAFFR in the interventional diagnosis of coronary artery disease compared with the conventional FFR. Methods:38 patients with known or suspected coronary artery disease were enrolled in our study, from January 2012 to December 2014, including 23 males and 15 females, and the average age (60.47±8.2). Invasive coronary angiography(CAG) with fractional flow reserve(FFR) were performed in these patients．Computation of CAFFR was derived from CAG data, using computational fluid dynamics algorithm by automatic calculation of coronary blood flow reserve fraction. Specificity accuracy CAFFR was calculated with invasive FFR as the reference. Results：FFR and CAFFR were applied for targeted lesion，Of the 38 patients and 42 vessels, There was a good correlation of vessel based CAFFR values with FFR value (r=0.661, P < 0.001). Conclusion：With the use of automatic calculation of coronary blood flow reserve fraction, CAFFR was proved to be a novel method for evaluating functional of coronary stenosis．CAFFR has good clinical value in interventional diagnosis and treatment of coronary artery disease.

       

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