Abstract: ob＜x＞jective To investigate the clinical and imaging features of Autoimmune encephalitis Methods A total of 19 patients who were with diagnosed as autoimmune encephalitis in the affiliated hospital of Xuzhou Medical University from June 2016 to October 2019 were enrolled in this study．Their clinical manifestations, cerebrospinal fluid examination, imaging, EEG examination and treatment prognosis were retrospectively analyzed..Results 1.Among the 19 patients , 14 were male and 5 were female, aged 18 to 68 years, with an average age of 42.1 ± 16.0 years.2.Clinical manifestations:13 cases of seizures, 11 cases of mental and behavioral disorders, 10 cases of cognitive impairment, 4 cases of speech disorder, 4 cases of decreased consciousness or coma, 3 cases of autonomic dysfunction, 3 cases of sleep disorder, 3 cases of central hypoventilation , 1 case of diarrhea and 1 case of hyponatremia.3.Cerebrospinal fluid examination: 18 cases of increased white blood cell count, 10 cases of increased protein, 11 cases of increased immunoglobulin IgG and 7 cases of lymphocytosis.4.Imaging features: The head MRI examination mainly showed high signal in T2WI and FLAIR in frontal lobe, temporal lobe, hippocampus, and island lobe, and some patients showed high signal in DWI. It is rare for enhanced scan with intensive scan.EEG: 6 cases were normal, 5 cases were mildly abnormal, 4 cases were moderately abnormal, and 1 case was severely abnormal.5.Treatment and prognosis: Most patients received glucocorticoids, immunoglobulins and other immunotherapy treatments, and their MRS scores were lower by 1-3 points than admitted to the hospital. Six patients recovered completely, and one patient abandoned treatment.Conclusion The clinical manifestations of autoimmune encephalitis are complex and diverse. In clinical work, patients with acute or subacute onset of epileptic seizures, mental and behavioral abnormalities and cognitive disorders should consider the possibility of autoimmune encephalitis, improve cerebrospinal fluid, brain MRI and start immunotherapy as soon as possible.