Abstract: ob＜x＞jective To investigate Novel Coronavirus Pneumonia (NCP) patie-nts with liver injury and the clinical value of preventive using liver protectingdrugs.Methods 66 patients with NCP diagnosed in Huai’an from January 23,2020 to March 9,2020 were collected,divided into observation group (n=34) and control group (n=32).The observation group was treated with antiviral therapy and preventive liver protection therapy,the control group was treated with antiviral therapy.The liver function indexes(ALT,AST,ALP,GGT)were tested before treatment,1 week and 2 weeks after treatment.Results There were no signific-ant difference in ALT,AST between the two groups before treatment(P>0.05); After 1 and 2 weeks of treatment, ALT, AST in the observation gr-oup were lower than those in the control group (P<0.05); there were no significant difference between the two groups in ALP, GGT before treatmen,at 1 and 2 weeks after treatment (P>0.05).Conclusion Preventive use of liver protecting drugs has protective effects on patients with Novel Coronavirus Pneumonia.