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    李群, 邱婷婷, 王莹, 徐开林, 李振宇, 李德鹏, 毛晓蕾. 异基因造血干细胞移植后EB病毒感染的临床分析[J]. 徐州医科大学学报, 2021, 41(8): 554-558.
    引用本文: 李群, 邱婷婷, 王莹, 徐开林, 李振宇, 李德鹏, 毛晓蕾. 异基因造血干细胞移植后EB病毒感染的临床分析[J]. 徐州医科大学学报, 2021, 41(8): 554-558.
    shu
    The clinical analysis of EBV infection after allo-HSCT[J]. Journal of Xuzhou Medical University, 2021, 41(8): 554-558.
    Citation: The clinical analysis of EBV infection after allo-HSCT[J]. Journal of Xuzhou Medical University, 2021, 41(8): 554-558.
    shu

    异基因造血干细胞移植后EB病毒感染的临床分析

    The clinical analysis of EBV infection after allo-HSCT

      摘要
    • 摘要: 目的：探讨异基因造血干细胞移植术后EB病毒（EBV）感染的发生率、危险因素，为allo-HSCT后EBV感染的防治提供依据。方法：通过回顾性分析2014年12月1日至2019年1月31日137例在我院行异基因造血干细胞移植患者的临床数据，统计allo-HSCT术后EB病毒感染的发生率、中位发生时间并综合分析移植后患者发生EBV感染的相关危险因素。结果：137例患者中男72例，女65例，中位年龄35(18～59)岁，共有77例患者发生EBV感染，1年累积发生率为56.2%，发生的中位时间为 55（17~257）d ，其中66例患者发生在移植后100天内，占全部EBV感染者的85.71%。共3例患者发生PTLD，累积发生率2.2%。移植前EBV-DNA阳性患者在移植后EBV感染率(70.6％)明显高于移植前EBV-DNA阴性患者(54.2％)，但两者之间的差异无显著性 (P=0.202)。单因素及多因素分析均提示预处理过程中预处理时采用抗胸腺细胞免疫球蛋白（ATG）、HLA不全相合移植、慢性移植物抗宿主病（cGVHD）及移植后CMV感染是allo-HSCT后发生EBV感染的独立危险因素。 结论:EB病毒感染是异基因造血干细胞移植后常见并发症，感染发生率较高。EBV感染发生的独立危险因素为预处理过程中采用ATG、HLA不全相合移植、cGVHD及移植后CMV感染。

       

      Abstract: ob＜x＞jective：To investigate the incidence and risk factors of Epstein Barr virus (EBV) infection after allogeneic hematopoietic stem cell transplantation (alloHSCT). Methods: the clinical data of 137 patients who underwent allogeneic hematopoietic stem cell transplantation in our hospital from December 1, 2014 to January 31, 2019 were retrospectively analyzed. The incidence and median time of EBV infection after allo HSCT were analyzed, and the risk factors of EBV infection after allo HSCT were analyzed. Results: there were 72 males and 65 females in 137 patients, with a median age of 35 (18-59) years. A total of 77 patients developed EBV infection. The 1-year cumulative incidence rate was 56.2%, and the median time of occurrence was 55 (17-257) days. Among them, 66 cases occurred within 100 days after transplantation, accounting for 85.71% of all EBV infection cases. PTLD occurred in 3 patients (2.2%). The infection rate of EBV-DNA positive patients before transplantation (70.6%) was higher than that of EBV-DNA negative patients before transplantation (54.2%), but the difference was not significant (P = 0.202).. Univariate and multivariate analysis showed that the use of antithymocyte immunoglobulin (ATG), HLA mismatched transplantation, chronic graft versus host disease (cGVHD) and CMV infection were independent risk factors for EBV infection after allo HSCT.Conclusion:Epstein Barr virus infection is a common complication after allogeneic hematopoietic stem cell transplantation. The independent risk factors of EBV infection were ATG, HLA mismatched transplantation, cGVHD and CMV infection after transplantation.*基金项目：国家自然科学基金（No：81400129）；中国博士后科学基金（No：2015113010）

       

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