[1]孔德强,王昱,齐敦益. 右美托咪定联合地佐辛在老年患者诊断性刮宫术中的临床应用[J].徐州医科大学学报,2017,37(07):436-438.
 KONG Deqiang,WANG Yu,QI Dunyi. Effects of dexmedetomidine combined with dezocine in elderly patients during diagnostic curettage[J].Journal of Xuzhou Medical University,2017,37(07):436-438.
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 右美托咪定联合地佐辛在老年患者诊断性刮宫术中的临床应用()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
37
期数:
2017年07期
页码:
436-438
栏目:
出版日期:
2017-07-25

文章信息/Info

Title:
 Effects of dexmedetomidine combined with dezocine in elderly patients during diagnostic curettage
作者:
 孔德强王昱齐敦益
 徐州医科大学附属医院麻醉科,江苏徐州221002
Author(s):
 KONG Deqiang WANG Yu QI Dunyi
 Department of Anesthesiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China
关键词:
 右美托咪定地佐辛老年诊断性刮宫
Keywords:
 dexmedetomidine dezocine elderly diagnostic curettage
分类号:
R614.2
文献标志码:
A
摘要:
 目的探讨右美托咪定联合地佐辛在老年患者诊断性刮宫中的麻醉效果。方法拟行诊断性刮宫术的老年患者40例,年龄70~83岁,随机分为右美托咪定组(D组)和丙泊酚组(P组),每组20例。D组静脉注射地佐辛0.1 mg/kg,同时泵注右美托咪定,负荷剂量为 0.8 μg/kg,持续10 min,然后以 0.5 μg/(kg·h)维持。P组静脉注射丙泊酚 1.5 mg/kg,地佐辛0.1 mg/kg后泵注丙泊酚 3~6 mg/(kg·h)维持。观察并记录患者麻醉前(T0)、OAA/S评分达到3级时(T1)、扩宫颈时(T2)以及术毕时(T3)的平均动脉压(MAP)、心率(HR)和脉搏氧饱和度(SpO2),同时观察患者术中呼吸抑制、舌根后坠和术中知晓情况,术后记录苏醒时间及苏醒期OAA/S评分。结果D组术中血压波动小于P组,呼吸抑制、舌根后坠发生率低于P组,2组患者均未发生术中知晓;术后D组清醒程度优于P组(P<0.05)。结论右美托咪定联合地佐辛用于老年患者诊断性刮宫术具有良好的麻醉效果,并且安全性更高、不良反应发生率更低。
Abstract:
 ObjectiveTo evaluate the effects of dexmedetomidine combined with dezocine in elderly patients undergoing dilatation and curettage. MethodsA total of 40 elderly patients (70-83years older) undergoing dilatation and curettage were selected and randomly divided into two groups: group D (dexmedetomidine group) and group P (propofol group),with 20 patients in each group. The patients in group D were received dexmedetomidine(0.8 μg /kg, the infusion time was set to 10 min and the maintenance dose of dexmedetomidine injection was 0.5 μg/(kg·h), dezocine 0.1 mg/kg .The patients in group P were received propofol 1.5 mg/kg (maintenance dose of propofol was 3-6 mg/(kg·h) and dezocine 0.1 mg/kg. The mean arterial pressure (MBP), heart rate (HR) and SpO2 of the two groups were recorded before anesthesia (T0), when OAA/S =3 (T1), when cervical dilation started (T2) and after surgery (T3). Meanwhile, respiratory depression, glossoptosis, intraoperative awareness, sedation scores and OAA/S scores during the awaking period were also recorded. ResultsGroup D showed more stable blood pressure, a less incidence rate of respiratory depression and glossoptosis than Group P (P<0.05). Intraoperative awareness did not happen in both group, while patients in Group D showed better awareness than those in Group P (P<0.05). ConclusionIt is safe and effective to use dexmedetomidine combined with dezocine in elderly patients during diagnostic and curettage.

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备注/Memo

备注/Memo:
 收稿日期:2017-05-05修回日期:2017-06-28
更新日期/Last Update: 2017-07-14