Abstract: Objective To compare the effects of 7.5% hypertonic saline and 20% mannitol on coagulation during supratentorial tumor resection. MethodsA total of 52 patients who were scheduled to receive supratentoraial tumor resection were divided into two groups: a 7.5% hypertonic saline group (HS) and 20% mannitol group (M) (n=26). Patients in each group were infused with 2.5 ml/kg of either 7.5% hypertonic saline or 20% mannitol for intraoperative brain relaxation before craniotomy. The following indexes were recorded before infusion (T0), and 30 min (T1) and 60 min (T2) after infusion: TEG indexes (R, K, α, MA, CI), CCT indexes (PT, APTT, Fib, Hb, Hct) and electrolytes (Na+, K+, Hb, Hct) and fluid intake and outtake volumes. The amounts of intravenous infusion, urinary output and bleeding were recorded. ResultsCompared with Group M, Group HS showed increases in R, α angle, APTT and the concentration of Na+, but decreases in K, Fib and Hct at T1, as well as increases in α angle and the concentration of Na+ but decreases in K, Fib, Hb and Hct at T2. ConclusionsCompared with 20% mannitol, 7.5% hypertonic saline produces smaller effects on coagulation during supratentorial tumor resection.