[1]王昱,王光磊,齐敦益*.盐酸羟考酮用于剖宫产术后静脉自控镇痛的临床观察[J].徐州医科大学学报,2017,37(11):718-720.
 WANG Yu,WANG Guanglei,QI Dunyi*.Clinical observation of oxycodone hydrochloride for patient-controlled analgesia in patients after cesarean section[J].Journal of Xuzhou Medical University,2017,37(11):718-720.
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盐酸羟考酮用于剖宫产术后静脉自控镇痛的临床观察()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
37
期数:
2017年11期
页码:
718-720
栏目:
出版日期:
2017-11-25

文章信息/Info

Title:
Clinical observation of oxycodone hydrochloride for patient-controlled analgesia in patients after cesarean section
作者:
王昱王光磊齐敦益*
徐州医科大学附属医院麻醉科,江苏徐州221002
Author(s):
WANG Yu WANG Guanglei QI Dunyi*
Department of Anesthesiology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China
关键词:
盐酸羟考酮剖宫产术后镇痛
Keywords:
oxycodone hydrochloride cesarean section postoperative analgesia
分类号:
R614.4
文献标志码:
A
摘要:
目的观察盐酸羟考酮用于剖宫产术后患者自控静脉镇痛(PCIA)的安全性、有效性。方法选取我院2016年8月—12月行择期剖宫产术的患者60例,ASA分级Ⅰ~Ⅱ级,行腰硬联合麻醉,术后静脉自控镇痛。随机分为2组,每组30例。S组:枸橼酸舒芬太尼注射液2 μg/kg+托烷司琼5 mg+生理盐水稀释至100 ml;O组:盐酸羟考酮注射液0.5 mg/kg+托烷司琼5 mg+生理盐水稀释至100 ml。背景输注速度为2 ml/h,PCIA量为0.5 ml,锁定时间为15 min。观察患者术后6、12、24、48 h的切口疼痛、宫缩疼痛及Ramsay评分。记录补救次数及剂量。记录患者48 h内不良反应发生率。结果术后各时间点O组的宫缩痛VAS评分均低于S组,差异有统计学意义(P<0.05);术后6、12 h时O组的Ramsay评分低于S组,差异有统计学意义(P<0.05)。2组患者恶心、呕吐、皮肤瘙痒发生率的差异均无统计学意义(P>0.05)。S组的补救次数多于O组,差异有统计学意义(P<0.05)。结论盐酸羟考酮注射液用于剖宫产患者的术后静脉自控镇痛安全有效,不良反应发生率低。
Abstract:
ObjectiveTo observe the safety and effectiveness of oxycodone hydrochloride for patient-controlled analgesia (PCA) in patients after cesarean section. MethodsA total of 60 patients (ASA Ⅰ-Ⅱ) scheduled for cesarean section from August to December 2016 in our hospital were selected. They underwent combined spinal epidural anesthesia followed by postoperative PCA. The patients were randomly divided into two groups (n=30): Group S which received 2 g/kg sufentanil citrate injection and 5 mg tropisetron in 100 ml normal saline and Group O which were given 0.5 mg/kg oxycodone hydrochloride injection and 5 mg tropisetron in 100 ml normal saline. The background infusion rate was 2 ml/h, the PCA amount was 0.5 ml, and the locking time was 15 min. Then, the incision pain, uterine contraction pain and Ramsay score were recorded 6, 12, 24 and 48 after surgery. Meanwhile, the time and doses of remediation were also recorded. The incidence of adverse reactions within 48 h was recorded. ResultsGroup O showed remarkably decreased VAS scores of uterine contraction pain compared with Group S at each time point after operation (P<0.05). The Ramsay score of Group O was significantly lower than that of Group S 6 h and 12 h after operation (P<0.05). The incidence of nausea, vomiting and itchy skin was not statistical different between the two groups (P>0.05). The frequency of remedial measures used in Group S was significantly high than that in Group O (P<0.05). ConclusionOxycodone hydrochloride injection is safe and effective for PCA in patients after cesarean section, with a low incidence of adverse reactions.

参考文献/References:

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更新日期/Last Update: 2017-12-06