[1]苗慧,刘亚洲*,邵卫仙,等.累及野放疗联合替吉奥治疗非手术老年食管癌的近期疗效观察[J].徐州医科大学学报,2017,37(11):738-742.
 MIALO Hui,LIU Yazhou*,SHAO Weixian,et al.Observation on the short-term effects of intensity-modulated radiation therapy combined with tegafur in the treatment of elderly patients with esophageal carcinoma[J].Journal of Xuzhou Medical University,2017,37(11):738-742.
点击复制

累及野放疗联合替吉奥治疗非手术老年食管癌的近期疗效观察()
分享到:

《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
37
期数:
2017年11期
页码:
738-742
栏目:
出版日期:
2017-11-25

文章信息/Info

Title:
Observation on the short-term effects of intensity-modulated radiation therapy combined with tegafur in the treatment of elderly patients with esophageal carcinoma
作者:
苗慧刘亚洲* 邵卫仙张文袁成施林心陈宏林孙赓姝
(江苏省徐州市肿瘤医院放射治疗科,江苏徐州221002)
Author(s):
MIALO Hui LIU Yazhou* SHAO Weixian ZHANG Wen YUAN Cheng SHI Linxin CHEN Honglin SUN Gengshu
(Department of Radiation Oncology, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221002, China)
关键词:
食管癌 累及野调强放疗 同步放化疗
Keywords:
esophageal cancer intensity-modulated radiation therapy tegafur
分类号:
R735.1
文献标志码:
A
摘要:
目的观察累及野放疗联合替吉奥治疗非手术老年食管癌的近期疗效和不良反应。方法选择我院2013—2015年收治的非手术老年食管癌患者64例,随机分为放疗+替吉奥组(联合组34例)和单纯放疗组(单放组30例),放疗采用累及野调强放疗,单次剂量1.8~2.0 Gy,每周5次,给予放疗总量50~60 Gy/25~30次;联合组放疗日给予替吉奥80 mg口服,至放疗结束。结果联合组和单放组的总有效率RR分别为82.4%(28/34)和60.0%(18/30),2组差异具有统计学意义(P=0.047)。联合组和单放组的完全缓解率分别为20.6%(7/34)和13.3%(4/30),联合组和单放组的1年生存率分别为50.0%(17/34)和43.3%(13/30),2组差异均无统计学意义(P>0.05)。联合组和单放组胃肠道反应的发生率分别为47.1%(16/34)和16.7%(5/30)(P=0.010),骨髓抑制发生率分别为64.7%(22/34)和33.3%(10/30)(P=0.012),差异均有统计学意义。结论累及野放疗联合替吉奥提高了非手术老年食管癌的总有效率,增加了骨髓抑制和消化道反应发生率,但毒副反应可以耐受。
Abstract:
ObjectiveTo observe the short-term effects and adverse effects of intensity-modulated radiation therapy combined with tegafur on elderly patients with esophageal cancer. MethodsA total of 64 elderly esophageal cancer patients without surgical treatment who were admitted into our hospital from 2013 to 2015 were enrolled. They were randomly divided into two groups: a radiotherapy and tegafur group (the combined treatment group, n=34) and a radiotherapy group (n=30). The total radiation dose was 50-60 Gy, 25 to 30 times and the single dose was 1.8-2.0 Gy, five times per week. Patients in the combined treatment group received 80 mg tegafur until the end of radiotherapy. ResultsThe total effective rate was 82.4% (28/34) for the combined treatment group which was remarkably different from 60.0% (18/30) for the radiotherapy group (P=0.047). The one-year survival rate was 50.0% (17/34) for the combined treatment group which was remarkably different from 43.3% (13/30) for the radiotherapy group. The complete response rate was 20.6% (7/34) for the combined treatment group which was remarkably different from 13.3% (4/30) for the radiotherapy group (P<0.05). The incidence rate of gastrointestinal tract reaction was 47.1% (16/34) for the combined treatment group which was remarkably different from 16.7% (5/30) for the radiotherapy group (P=0.010). The incidence rate of bone marrow suppression was 64.7% (22/34) for the combined treatment group which was remarkably different from 33.3% (10/30) for the radiotherapy group (P=0.012). ConclusionsThe combination of involved-field irradiation and tegafur can increase the complete remission rate, and the incidence rate of gastrointestinal tract reaction and bone marrow suppression which can be tolerant.

参考文献/References:

1]姚元虎,章龙珍,吴阳,等.80岁以上高龄老年食管癌患者调强放射治疗的临床分析[J].中国老年学杂志,2012,32(19):4149-4150. [2]张宜勤,陆进成,翟振宇,等.三维适形放疗食管癌临床研究的初步结果[J].中华放射肿瘤学杂志,2005,14(1):31-34. [3]蒋杰,王奇峰,肖泽芬,等.132例食管癌三维适形放疗的疗效分析[J].中华放射肿瘤学杂志,2009,18(1):47-51. [4]Herskovic A, Martz K, al-Sarraf M, et al. Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus [J]. N Engl J Med, 1992,326(24):1593-1598. [5]Cooper JS, Guo MD, Herskovic A, et al. Chemoradiotherapy of locally advanced esophageal cancer: long-term follow-up of a prospective randomized trial (RTOG 85-01). Radiation Therapy Oncology Group [J]. JAMA, 1999,281(17):1623-1627. [6]Minsky BD1, Pajak TF, Ginsberg RJ,et al. INT 0123 (Radiation Therapy Oncology Group 94-05) phase III trial of combined-modality therapy for esophageal cancer: high-dose versus standard-dose radiation therapy [J].J Clin Oncol, 2002,20(5):1167-1174. [7]韩春,任雪姣,王澜,等.钡餐造影结合CT评价食管癌放疗近期疗效的研究[J].中华放射肿瘤学杂志,2013,22(1):26-29. [8]Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) [J]. Int J Radiat Oncol Biol Phys, 1995,31(5):1341-1346. [9]郭洪波,于金明,张百江,等.氟脱氧葡萄糖PET-CT确定食管癌淋巴结放疗靶区的可行性研究[J].中华放射肿瘤学杂志,2007,16(1):10-14. [10]Fu WH, Wang LH, Zhou ZM, et al. Comparison of conformal and intensity-modulated techniques for simultaneous integrated boost radiotherapy of upper esophageal carcinoma [J]. World J Gastroenterol, 2004,10(8):1098-1102. [11]史鸿云,祝淑钗,翟福山,等.食管癌病理特点对放疗靶区的影响[J].中华放射肿瘤学杂志,2006,15(4):280-284. [12]郭建文,山长平,班新能,等.老年食管癌的循证医学治疗[J].现代肿瘤医学,2009,17(3):457-459. [13]李涛,朱卫国,韩济华,等.三维适形放射治疗联合卡莫氟治疗老年食管癌的临床观察[J].现代肿瘤医学,2011,19(8):1573-1576. [14]闫海山.放疗联合希罗达和单纯放疗对老年食管癌生活质量的影响[J].医学理论与实践,2015,28(15):2019-2020. [15]祝淑钗,李任,王玉祥,等.500例中晚期食管癌单纯放疗的多因素分析[J].中华放射肿瘤学杂志,2005,14(4):253-258. [16]王鑫,金晶,任骅,等.局部晚期胃癌术后替吉奥同期IMRT的Ⅰ期临床研究[J].中华放射肿瘤学杂志,2014,23(4):282-285. [17]王鑫,唐源,金晶,等.局部晚期胃癌术后S-1同期IMRT的Ⅱ期临床研究中期分析[J].中华放射肿瘤学杂志,2016,25(4):351-355. [18]马丽莉,李水仙,毕志彬. PD-L1和PD-L2在食管鳞状细胞癌表达增强并与浸润和转移有关[J].细胞与分子免疫学杂志,2015,31(8):1112-1114.

相似文献/References:

[1]耿晓如,张鑫君,李连涛,等.系统免疫炎症指数与老年食管癌预后的关系[J].徐州医科大学学报,2017,37(12):779.
 GENG Xiaoru,ZHANG Xinjun,LI Liantao,et al.Effects of systemic immune-inflammation indexes on the prognosis of elderly patients with esophageal cancer[J].Journal of Xuzhou Medical University,2017,37(11):779.
[2]高立艳,张兰胜,许慧琴,等.食管癌NRF2表达预测放疗敏感性的临床价值[J].徐州医科大学学报,2021,41(05):363.[doi:10.3969/j.issn.2096-3882.2021.05.011]
[3]楚建军、叶本法.淮安市食管癌发病因素的岭回归分析[J].徐州医科大学学报,1992,12(02):85.
 [J].Journal of Xuzhou Medical University,1992,12(11):85.
[4]胡正群、白相春、俞晖.食管癌贲门癌术后残端癌15例分析[J].徐州医科大学学报,1992,12(02):134.
 [J].Journal of Xuzhou Medical University,1992,12(11):134.
[5]刘绪军、王洪雷、毕伟.机械吻合与手工吻合治疗中上段食管癌的临床疗效观察[J].徐州医科大学学报,2010,30(11):749.
 [J].Journal of Xuzhou Medical University,2010,30(11):749.
[6]王亚勤、方良伟、田小丰、贡力、卞钧、胡海波、朱大伟.老年食管癌患者围手术期肺部并发症的诊治[J].徐州医科大学学报,2008,28(02):121.
 [J].Journal of Xuzhou Medical University,2008,28(11):121.
[7]李树坤、董立峰、杨新勇.食管癌穿孔放置支架后放射治疗的临床观察[J].徐州医科大学学报,2001,21(03):224.
 [J].Journal of Xuzhou Medical University,2001,21(11):224.
[8]赵文静.吗啡及吗啡布比卡因合剂用于食管癌术后硬膜外镇痛的比较[J].徐州医科大学学报,2001,21(04):275.
 [J].Journal of Xuzhou Medical University,2001,21(11):275.
[9]王伟、王善政、杨国涛等.血管内皮生长因子在食管癌中的表达[J].徐州医科大学学报,2001,21(05):362.
 [J].Journal of Xuzhou Medical University,2001,21(11):362.
[10]陈桂明.食管癌、贲门癌术中罕见医源性器官损伤的预防和处理[J].徐州医科大学学报,2001,21(05):407.
 [J].Journal of Xuzhou Medical University,2001,21(11):407.

备注/Memo

备注/Memo:
基金项目:江苏大学医学临床科技发展基金项目(JLY20140115) *通信作者, Email:asiadoc@126.com
更新日期/Last Update: 2017-12-06