[1]周瑜,张瑞,樊华秀,等. 溴隐亭对小鼠实验性胃溃疡的影响[J].徐州医科大学学报,2018,38(01):59-62.
 ZHOU Yu,ZHANG Rui,FAN Huaxiu,et al. Effects of bromocriptine on experimental gastric ulcer in mice[J].Journal of Xuzhou Medical University,2018,38(01):59-62.
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 溴隐亭对小鼠实验性胃溃疡的影响()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
38
期数:
2018年01期
页码:
59-62
栏目:
出版日期:
2018-01-25

文章信息/Info

Title:
 Effects of bromocriptine on experimental gastric ulcer in mice
作者:
周瑜1张瑞1樊华秀1杨倩倩1王升艳1陈瑾1黄晨雨1王丹2*
(1. 徐州医科大学麻醉学院2014级,江苏徐州221004; 2.徐州医科大学麻醉药理学教研室)
Author(s):
 ZHOU Yu1 ZHANG Rui1 FAN Huaxiu1 YANG Qianqian1 WANG Shengyan1CHEN Jin1 HUANG Chenyu1 WANG Dan2*
1.Grade 2014, School of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China;
2.Department of Anesthetic Pharmacology, Xuzhou Medical University)
关键词:
 胃溃疡溴隐亭束缚浸水法阿司匹林小鼠
Keywords:
gastric ulcer bromocptine water immersion restraint method aspirin mice
分类号:
R573.1
文献标志码:
A
摘要:
目的探讨溴隐亭(bromocriptine,Brc)对小鼠实验性胃溃疡的影响。方法束缚浸水法:将小鼠随机分为空白对照组(C组)、束缚浸水模型组(W组)和溴隐亭预防组(Brc+W组),每组10只。Brc+W组给予2.5 mg·kg-1溴隐亭灌胃预处理,30 min后与W组小鼠同时束缚浸水,9 h后检测小鼠内脏痛指数和胃溃疡指数。阿司匹林法:将小鼠随机分为空白对照组(C组)、阿司匹林模型组(Asp组)和溴隐亭预防组(Brc+Asp组),每组10只。Brc+Asp组给予2.5 mg · kg-1溴隐亭灌胃预处理,30 min后与Asp组小鼠同时给予300 mg · kg-1阿司匹林灌胃,1 h后检测小鼠内脏痛指数和胃溃疡指数。结果束缚浸水法:与C组比较,W组内脏痛指数和胃溃疡指数明显升高(P<0.01)。与W组比较,Brc+W组内脏痛指数和胃溃疡指数明显下降(P<0.01)。阿司匹林法:与C组比较,Asp组内脏痛指数和胃溃疡指数明显升高(P<0.01)。与Asp组比较,Brc+Asp组内脏痛指数和胃溃疡指数明显下降(P<0.01)。结论预先给予溴隐亭对束缚浸水和阿司匹林所致的胃溃疡均有保护作用。
Abstract:
 ObjectiveTo observe the effects of bromocriptine on experimental gastric ulcer in mice. MethodsWater immersion restraint method: Mice were randomly divided into three groups (n=10): a control group (Group C), a water immersion restraint model group (Group W) and a bromocriptine prevention group (Group Brc + W). Mice in the Group Brc+W were pretreated with 2.5 mg·kg-1 bromocriptine through intragastric administration, and half an hour later received water immersion restraint with Group W. Then, 9 hours later, their visceral pain index and gastric ulcer index were measured. Aspirin method: Mice were randomly divided into three groups (n=10): a control group (Group C), an aspirin model group (Group Asp) and a bromocriptine prevention group (Group Brc+Asp). Mice in the Group Brc+Asp were pretreated with 2.5 mg·kg-1 bromocriptine through intragastric administration, and half an hour later given 300 mg·kg-1 aspirin through intragastric administration with Group Asp. Then, 1 hour later, their visceral pain index and gastric ulcer index were measured. ResultsWater immersion restraint method: Compared with the C group, the visceral pain index and gastric ulcer index were significantly increased in the W group (P<0.01). Compared with the W group, the visceral pain index and gastric ulcer index were significantly decreased in the Brc+W group (P<0.01). Aspirin method: Compared with the C group, the visceral pain index and gastric ulcer index were significantly increased in the Asp group (P<0.01). Compared with the Asp group, the visceral pain index and gastric ulcer index were significantly decreased in the Brc+Asp group (P<0.01). Conclusions Pretreatment with bromocriptine has protective effects on gastric ulcers induced by water immersion restraint and aspirin.

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收稿日期:2017-10-15修回日期:2017-11-30

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备注/Memo

备注/Memo:
 基金项目:江苏高校品牌专业建设工程项目(PPZY2015A066)
*通信作者:E-mail:wdmingtiangenghao@126.com
更新日期/Last Update: 2018-04-12