[1]张凯,张剑锋,何兴状,等.18例胃肝样腺癌患者临床病理特点及预后分析[J].徐州医科大学学报,2017,37(11):734-737.
　ZHANG Kai,ZHANG Jianfeng,HE Xingzhuang,et al.The clinicopathological features and prognostic analysis of 18 patients with hepatoid adenocarcinoma of the stomach[J].Journal of Xuzhou Medical University,2017,37(11):734-737.
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18例胃肝样腺癌患者临床病理特点及预后分析()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
37
期数:
2017年11期
页码:
734-737
栏目:
出版日期:
2017-11-25

文章信息/Info

Title:
The clinicopathological features and prognostic analysis of 18 patients with hepatoid adenocarcinoma of the stomach
作者:
张凯1; 张剑锋1; 何兴状2; 余伦3; 侯英奎1
(1.广元市第一人民医院普外科，四川广元628000；2.广元市第一人民医院病理科； 3. 广元市中心医院普外科，四川广元628000)
Author(s):
ZHANG Kai1;  ZHANG Jianfeng1;  HE Xingzhuang2;  YU Lun3;  HOU Yingkui1
1.Department of General Surgery, the First People′s Hospital of Guangyuan, Guangyuan, Sichuan 628000, China;2.Department of Pathology, the First People′s Hospital of Guangyuan; 3.Department of General Surgery, Guangyuan Central Hospital, Guangyuan, Sichuan 628000)
关键词:
胃肝样腺癌; 肝转移; 外科治疗
Keywords:
hepatoid adenocarcinoma of the stomach;  liver metatasis;  surgical therapy
文献标志码:
A
摘要:
目的研究胃肝样腺癌的临床病理特点及预后因素，以改善其诊断及治疗。方法回顾性研究广元市第一人民医院和广元市中心医院近20年来收治的18例胃肝样腺癌的临床病理资料，研究分析其临床特点、危险因素及预后。结果18例病例均出现淋巴结转移，5例术前发生肝脏转移。病理分期、是否接受根治性手术治疗、是否接受辅助化疗为影响患者预后的相关危险因素（P<0.05)。本组病例3年累积无病生存率为7.1%，3年累积总生存率为9.9%。结论胃肝样腺癌是具有高度恶性的一类特殊胃癌，在临床及病理诊断中极易误诊，其预后较差，早期诊断、早期多学科治疗是改善该类疾病的关键。
Abstract:
ObjectiveTo investigate the clinical, pathological features and prognostic factors of hepatoid adenocarcinoma of the stomach (HAS), so as to improve the diagnosis and treatment of HAS. MethodsA total of 18 HAS patients who were admitted into the First People’s Hospital of Guangyuan and Guangyuan Central Hospital in the past twenty years were enrolled. Their clinical features, risk factors and prognosis were analyzed. ResultsAll patients presented lymphatic metastasis, where five patients showed liver metastasis before surgery. Pathologic staging, radical surgery and adjuvant chemotherapy were the risk factors for HAS patients (P<0.05). In the current study, the 3-year overall survival rate was 9.9%, while the 3-year disease-free survival rate was 7.1%. ConclusionsHAS is a highly malignant tumor, which is often easily misdiagnosed with very poor prognosis. Early diagnosis and early multidisciplinary treatment are essential to treat HAS.

参考文献/References:

［1］Ishikura H, Fukasawa Y, Ogasawara K, et al. An AFP-producing gastric carcinoma with features of hepatic differentiation. A case report ［J］. Cancer, 1985, 56（4）:840-848. ［2］Terracciano ML, Glatz K, Mhawech P, et al. Hepatoid adenocarcinoma with liver metastasis mimicking hepatocellular carcinoma: an immunohistochemical and molecular study of eight cases ［J］. Am J Surg Pathol, 2003,27(10):1302-1312. ［3］Otsuki Y, Shimizu S, Hosoda Y, et al. Hepatocellular carcinoma with mesothelioma-like dissemination ［J］. Pathol Intern, 2005,55(11):738-744. ［4］茅翔，罗奋，陈宗祐,等.提高对胃肝样腺癌和产甲胎蛋白胃癌的认识［J］.中华肿瘤杂志，2015，20（6）:156-158. ［5］邵国益，张献，胡根，等.AFP阳性胃肝样腺癌15例临床分析［J］.现代肿瘤医学，2015,12（21）:204-205. ［6］Kono K, Amenfiya H, Sekikawa T, et al. Clinicopathologic features of gastric cancers producing alpha-fetoprotein ［J］. Dig Surg, 2002,19(5):359-365． ［7］Roberts CC, Colby TV, Batts KP. Carcinoma of the stomach with hepatocyte differentiation(hepatoid adenocarcinoma) ［J］. Mayo Clin Proc, 1997,72(12):1154-1160. ［8］Zhang JF, Shi SS, Shao YF, et al. Clinicopathological and prognostic features of hepatoid adenocarcinoma of the stomach ［J］. Chin Med J （Engl）, 2011,124(10):1470-1476.

相似文献/References:

[1]张凯、张剑锋、何兴状、余伦、侯英奎.18例脱肝样腺癌患者临床病理特点及预后分析[J].徐州医科大学学报,2017,37(11):734.
　[J].Journal of Xuzhou Medical University,2017,37(11):734.

备注/Memo

备注/Memo:
收稿日期：2017-03-26修回日期：2017-10-14 本文编辑：吴进
更新日期/Last Update: 2017-12-06