[1]朱巧英,丁炎,周锋盛,等. 影响无水乙醇消融治疗囊性为主甲状腺良性结节疗效的因素及对策[J].徐州医科大学学报,2018,38(01):42-45.
 ZHU Qiaoying,DING Yan,ZHOU Fengsheng,et al. The influencing factors of anhydrous ethanol ablation in the treatment of benign cystic thyroid nodules[J].Journal of Xuzhou Medical University,2018,38(01):42-45.
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 影响无水乙醇消融治疗囊性为主甲状腺良性结节
疗效的因素及对策
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
38
期数:
2018年01期
页码:
42-45
栏目:
出版日期:
2018-01-25

文章信息/Info

Title:
 The influencing factors of anhydrous ethanol ablation in the treatment
of benign cystic thyroid nodules
作者:
 朱巧英丁炎周锋盛蒋骁 陈俊宣旻吴鹏西*
 无锡市人民医院超声医学科,江苏无锡214023)
Author(s):
ZHU Qiaoying DING Yan ZHOU Fengsheng JANG Xiao CHEN Jun XUAN Min WU Pengxi*
Department of Medical Ultrasound, the People′s Hospital of Wuxi, Wixi, Jiangsu 214023, China)
关键词:
 无水乙醇甲状腺囊性结节独立预测因素
Keywords:
 anhydrous ethanol benign cystic thyroid nodules independent predictors
分类号:
R445.1
文献标志码:
A
摘要:
目的探讨无水乙醇消融治疗囊性为主的甲状腺良性结节疗效的影响因素及对策。方法选择2014年1月至2016年6月在无锡市人民医院超声医学科行无水乙醇消融治疗的102例甲状腺结节患者作为研究对象,评价治疗前后的结节体积变化。比较单纯乙醇冲洗与乙醇冲洗加局部注射2种方法对甲状腺囊性为主良性结节的治疗效果,并分析影响2种治疗方法疗效的因素。结果无水乙醇消融治疗后,甲状腺结节平均体积从(15.7±14.3)ml减少到(3.0±2.5)ml,治疗有效率为84.5%。其中,单纯乙醇冲洗组甲状腺结节的平均体积从(16.6±13.5)ml 缩小至(4.7±3.1)ml,治疗有效率达76.9%。乙醇冲洗加局部注射前后甲状腺结节的平均面积从(14.8±12.2)ml 缩小至(2.1±1.4)ml,治疗有效率达90.2%,乙醇冲洗加局部注射的治疗疗效高于单纯乙醇冲洗。对所有的结节而言,无水乙醇消融治疗疗效的独立预测因素包括治疗的方法、治疗前体积和实性成分。治疗前体积和实性成分是单纯乙醇冲洗治疗疗效的独立预测因素,没有独立的因素与乙醇冲洗加局部注射的疗效有关。结论单纯乙醇冲洗与乙醇冲洗加局部注射甲状腺囊性为主的结节具有疗效,单纯乙醇冲洗对体积大、实性成分多的甲状腺结节有效率低于乙醇冲洗加局部注射,乙醇冲洗加局部注射可提高无水乙醇消融甲状腺囊性为主的良性结节的疗效,且不受结节性质影响。
Abstract:
 ObjectiveTo investigate the influencing factors of anhydrous ethanol ablation in the treatment of benign cystic thyroid nodules and possible measures. MethodsA total of 102 benign cystic thyroid nodules patients who were treated with anhydrous ethanol in our department from January 2014 to June 2016 were enrolled in the study. The patients underwent ethanol flush or ethanol flush combined with local injection and their changes in the volume of nodules were evaluated before and after treatment, and the corresponding efficacies were compared. Meanwhile, the influencing factors of the above treatments were analyzed. ResultsAfter anhydrous ethanol ablation, the average volume of nodules were reduced from (15.7 ± 14.3) ml to (3.0 ± 2.5) ml, with an effective rate of 84.5%. Ethanol flush alone resulted in decreases in the average nodule volume from (16.6 ± 13.5) ml to (4.7 ± 3.1) ml, with an effective rate of 76.9%. Ethanol flush combined with local injection resulted in decreases in the average nodule volume from (14.8±12.2) ml to (2.1 ±1.4) ml, with an effective rate of 90.2%. The combined treatment showed a higher effective rate than ethanol flush alone. The independent predictors for the efficacy of anhydrous ethanol ablation include therapeutic methods, the volume before treatment volume and solid components of the nodules, where the volume before treatment volume and solid components of the nodules were the independent predictors for the efficacy of ethanol flush alone. No independent factor was found to be associated with the efficacy of the combined treatment. ConclusionsBoth ethanol flush and ethanol flush combined with local injection are effective to treat benign cystic thyroid nodules. Compared with ethanol flush alone, the combined treatment is more effective to treat nodules with large size or more solid components.

参考文献/References:

 [1]Bennedbaek FN, Hegedüs L. Treatment of recurrent thyroid cysts with ethanol: a randomized double-blind controlled trial [J]. J Clin Endocrinol Metab, 2003,88(12):5773-5777.
[2]Del Prete S, Caraglia M, Russo D, et al. Percutaneous ethanol injection efficacy in the treatment of large symptomatic thyroid cystic nodules: ten-year follow-up of a large series [J]. Thyroid, 2002,12(9):815-821.
[3]Kim DW, Rho MH, Kim HJ, et al. Percutaneous ethanol injection for benign cystic thyroid nodules: is aspiration of ethanol-mixed fluid advantageous? [J]. AJNR Am J Neuroradiol, 2005,26(8):2122-2127.
[4]Cho YS, Lee HK, Ahn IM, et al. Sonographically guided ethanol sclerotherapy for benign thyroid cysts: results in 22 patients [J]. AJR Am J Roentgenol, 2000,174(1):213-216.
[5]Kim JH, Lee HK, Lee JH, et al. Efficacy of sonographically guided percutaneous ethanol injection for treatment of thyroid cysts versus solid thyroid nodules [J]. AJR Am J Roentgenol, 2003,180(6):1723-1726.
[6]Kim YJ, Baek JH, Ha EJ, et al. Cystic versus predominantly cystic thyroid nodules: efficacy of ethanol ablation and analysis of related factors [J]. Eur Radiol, 2012,22(7):1573-1578.
[7]Lee JH, Kim YS, Lee D, et al. Radiofrequency ablation (RFA) of benign thyroid nodules in patients with incompletely resolved clinical problems after ethanol ablation (EA) [J]. World J Surg, 2010,34(7):1488-1493.
[8]Sung JY, Kim YS, Choi H, et al. Optimum first-line treatment technique for benign cystic thyroid nodules: ethanol ablation or radiofrequency ablation [J]. AJR Am J Roentgenol, 2011,196(2):W210-W214.
[9]Baek J H, Ha E J, Choi Y J, et al. Radiofrequency versus ethanol ablation for treating predominantly cystic thyroid nodules: a randomized clinical trial [J]. Korean J Radiol, 2015,16(6):1332.
[10]张燕,范晓翔,章美武.超声引导下甲状腺囊实性结节射频消融与酒精消融疗效比较[J].中华超声影像学杂志,2016,25(4):318-323.
收稿日期:2017-11-02修回日期:2017-12-09

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备注/Memo

备注/Memo:
基金项目:无锡市医管中心其他项目(YGZXQ1306)
*通信作者,Email:wipengxi2155@163.com
更新日期/Last Update: 2018-04-12