[1]张正伟谢晓玮,王海燕.茚达特罗与噻托溴铵治疗慢性阻塞性肺疾病的疗效比较[J].徐州医科大学学报,2019,39(07):498-501.
 Effects of Indacaterol and Tiotropium Bromide on Chronic Obstructive Pulmonary Disease[J].Journal of Xuzhou Medical University,2019,39(07):498-501.
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茚达特罗与噻托溴铵治疗慢性阻塞性肺疾病的疗效比较()
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《徐州医科大学学报》[ISSN:2096-3882/CN:32-1875/R]

卷:
39
期数:
2019年07期
页码:
498-501
栏目:
出版日期:
2019-06-25

文章信息/Info

Title:
Effects of Indacaterol and Tiotropium Bromide on Chronic Obstructive Pulmonary Disease
作者:
张正伟谢晓玮王海燕
文献标志码:
A
摘要:
目的:本文对比茚达特罗150μg、300μg和噻托溴铵18 μg对稳定期中度至重度COPD患者速效及长效的支气管扩张作用。方法:有125例患者完成实验,茚达特罗粉吸入剂150μɡ组 (n=42), 300μɡ组(n=41),噻托溴铵粉吸入剂18μɡ组(n=42)。主要的变量是给药前30min,给药后5min、30 min、1h、4h一秒钟用力呼气容积FEV1,及4周后FEV1谷值。和次要变量是在给药后4周六分钟步行试验(6 MWT)及CAT评分。 结果:两个剂量茚达特罗在给药5 min、30 min FEV1升高均较噻托溴铵有明显差异,给药30 min茚达特罗300μg 升高程度较150μg更为显著(P<0.05);给药1h、4h三药较基线均有升高,茚达特罗300μg FEV1提升较茚达特罗150μg组与噻托溴铵组更显著(P<0.05),茚达特罗150μg组与噻托溴铵组FEV1提升水平相同。给药持续4周可见茚达特罗300μg较茚达特罗150μg、噻托溴铵FEV1谷值改善更明显,茚达特罗150μg与噻托溴铵疗效相似。 三观察组CAT评分在持续治疗4周后均有显著下降。茚达特罗150μg组CAT评分下降水平与噻托溴铵组相比无显著差异。茚达特罗300μg 观察组CAT评分下降水平较茚达特罗150μg组与噻托溴铵组更为显著。治疗4周后3观察组6MWT均值有明显提升,茚达特罗150μg组与噻托溴铵组改善水平相当,茚达特罗300μg 观察组6MWT的提升水平较茚达特罗150μg组与噻托溴铵组更为显著。结论:茚达特罗150μg及300μg给药5分钟后FEV1迅速上升,给药30分钟后茚达特罗300μg升高程度较150μg更为显著,噻托溴铵FEV1在这两个时间点无显著提升。噻托溴铵相比茚达特罗150μg长效扩张支气管作用与噻托溴铵水平相当,高剂量组茚达特罗300 μg的长效扩张支气管作用优于低剂量组茚达特罗及噻托溴铵。茚达特罗300 μg改善患者呼吸困难水平及提高患者运动能力优于茚达特罗150μg、噻托溴铵18μg。
Abstract:
Objective: To observe the onset of action and long-acting of bronchodilator effect of two dose of indacaterol with tiotropium bromide in patients with stable moderate-to-severe COPD. Methods:125 patients with moderate and severe COPD stable period were randomly assigned into three groups, indacaterol 150μg n=42, indacaterol 300 μg n=41, and tiotropium bromide n=42 .The three groups were treated for 4 weeks.The spirometry was conducted at 30 minutes pre-medication and 5min, 30 min,1 hour, 4hour post-medication, 4 weeks after Treatment. Six minutes -walk test (6 MWT) and CAT index were compared between the three groups before and 4 weeks after treatment.Results:The forced expiratory volume in one second (FEVl) were significantly higher in the indacaterol 150, 300 μg arms than that of the tiotropium bromide arm, in 5min, 30 min post-medication(P<0.05). In 30 min post-medication FEVl was significantly higher in the indacaterol 300μg arm than that of the indacaterol 150μg arm(P<0.05).In 1 hour , 4 hour post-medication and 4 weeks after treatment FEVl was significantly higher in the indacaterol 300μg arm than that of the indacaterol 150μg arm and tiotropium bromide arm (P<0.05).By comparison with baseline,6 MWT and CAT index was significantly improved in the indacaterol 300μg arm than that of the indacaterol 150μg arm and tiotropium bromide arm 4 weeks after treatment (P<0.05).Conclusion: The results indicated that indacaterol 150 μg and 300 μg proved a faster onset of action than tiotropium bromide . The long effect dilated bronchiectas of indacaterol 300 are are better than those of indacaterol 150 μg and thiotropium bromide, indacaterol 150 μg equal to that of tiotropium arm.
更新日期/Last Update: 2019-07-11